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来源 纯度 E. coli. Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses 描述 产品目录编号 GF166 描述 BMP-2 Protein, Human Recombinant Alternate Names - BMP-2A
- Bone Morphogenetic Protein 2
- BMP2
背景信息 Bone morphogenetic protein 2 (BMP-2) is a member of the BMP subgroup of the TGFβ superfamily. It plays a dominant role in embryonic dorsalventral patterning, organogenesis, limb bud formation, and bone formation and regeneration. BMP-2 is a potent osteoinductive cytokine, capable of inducing bone and cartilage formation in association with osteoconductive carriers such as collagen and synthetic hydroxyapatite. In addition to its osteogenic activity, BMP-2 plays an important role in cardiac morphogenesis and is expressed in a variety of tissues including lung, spleen, brain, liver, prostate ovary and small intestine. The functional form of BMP-2 is a 26 kDa protein composed of two identical 114 amino acid polypeptide chains linked by a single disulfide bond. Each BMP-2 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 23 amino acid signal sequence for secretion, and a 259 amino acid propeptide. After dimerization of this precursor, the covalent bonds between the propeptide (which is also a disulfide-linked homodimer) and the mature BMP-2 ligand are cleaved by a furin-type protease. Recombinant human BMP-2 is a 26.0 kDa homodimeric protein consisting of two 115 amino acid polypeptide chains. 产品信息 演示 Product is filtered through a 0.2 micron filter before lyophilization. 应用 应用 The Human Bone morphogenetic protein 2 (or BMP-2 protein) is a member of the BMP protein subgroup of the TGFβ superfamily. 生物信息 纯度 Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses 来源 E. coli. 交叉反应性 Mouse, Rat, Rabbit, Cow, Dog, Monkey UniProt编号 - P12643
产品使用声明 质量保证 Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml. 储存和货运信息 存储条件 Store at -20°C for up to 6 months from date of receipt. 包装信息 数量 10 µg
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