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品种反应性 主要应用 宿主 格式 抗体类型 M, R, H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT119 描述 Anti-CELSR1 Antibody Alternate Names - hFmi2
- Cadherin EGF LAG seven-pass G-type receptor 1
- Cadherin family member 9
- Flamingo homolog 2
背景信息 The Flamingo/CELSR family of 7TM-cadherins are characterized with a symmetric protein distribution and polarized activity at neighboring epithelial cell interfaces along defined axes of planar cell polarity. As a component of the extracellular matrix, the CELSR1 protein has been found particularly at the basal surface of neuroepithelial cells within both the early neural tube and a less well-defined group of ventricular zone cells at the midline of the developing spinal cord. CELSR1 plays a role in orienting hair follicles along the anterior–posterior axis of the developing mouse epidermis, both during embryogenesis and postnatal development. 产品信息 格式 Affinity Purified 控制 - PC12 cell lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-CELSR1 Antibody is validated for use in Western Blotting, IHC, Immunofluorescence for the detection of CELSR1. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunofluorescence Analysis: A 1:500 and 1:1,000 dilution from a representative lot detected CELSR1 in rat cerebellum, substancia nigra, and hippocampus tissue.
Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected CELSR1 in neurons of rat cortex tissue and in Purkinje cells and cells within the granular layer of rat cerebellum tissue.生物信息 免疫原品种 Linear peptide corresponding to human CELSR1. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 MouseRatHuman Species Reactivity Note Demonstrated to react with Rat. Predicted to react with Human and Mouse based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_055061
Entrez基因汇总 The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. 基因符号 - FMI2
- CELSR1
- CDHF9
纯化方法 Affinity purified UniProt编号 - Q9NYQ6
UniProt汇总 FUNCTION: Receptor that may have an important role in cell/cell signaling during nervous system formation.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
POST-TRANSLATIONAL MODIFICATION: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 9 cadherin domains. Contains 8 EGF-like domains. Contains 1 GPS domain. Contains 1 laminin EGF-like domain. Contains 2 laminin G-like domains.产品使用声明 质量保证 Evaluated by Western Blot in PC12 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected CELSR1 in 10 µg of PC12 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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