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merck millipore,默克密理博,GF164,ANG-1 Protein, Human Recombinant
产品名称：ANG-1 Protein, Human Recombinant
产品型号：GF164
The Ang-1 protein & Ang-2 protein are secreted ligands which bind with similar affinity to Tie2, a receptor tyrosine kinase with immunoglobulin & epidermal growth factor homology domains expressed on More>>
merck millipore,默克密理博,GF164,ANG-1 Protein, Human Recombinant
- 产品介绍
重要规格表
来源 纯度 Hela Cells Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses 描述 产品目录编号 GF164 描述 ANG-1 Protein, Human Recombinant Alternate Names - angiopoietin-related protein 4
- ANG1
- Angiopoietin1
- Hepatic fibrinogen/angiopoietin-related protein
- PPARG angiopoietin related protein
- angiopoietin-like 4
- angiopoietin-like 4 protein
背景信息 Angiopoietin1 (Ang1) and Angiopoietin2 (Ang2) are two closely related secreted ligands which bind with similar affinity to Tie2,
a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells. Tie2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (Ang-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, Ang-1 enhances endothelial cell survival and capillary morphogenesis, and lessens capillary permeability. As such, Ang-1 has a potential to become an effective therapeutic agent for treating various endothelium disorders, including several severe human pulmonary diseases. Recombinant human ANG-1, derived from HeLa cells, is a C-terminal histidine tagged glycoprotein which migrates with an apparent molecular mass of 60.0 – 70.0 kDa by SDS-PAGE under reducing conditions. Sequencing analysis shows N-terminal sequences starting with Ser-20 and with Asp-70 of the 498 amino acid precursor protein.产品信息 演示 Product is filtered through a 0.2 micron filter before lyophilization. 应用 应用 The Ang-1 protein & Ang-2 protein are secreted ligands which bind with similar affinity to Tie2, a receptor tyrosine kinase with immunoglobulin & epidermal growth factor homology domains expressed on endothelial & early hematopoietic cells. 生物信息 纯度 Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 95% pure by SDS-PAGE gel and HPLC analyses 来源 Hela Cells 交叉反应性 None UniProt编号 - Q15389
产品使用声明 质量保证 Bioactivity assay: Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC). 储存和货运信息 存储条件 Store at -20°C for up to 6 months from date of receipt. 包装信息 数量 20 µg
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