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merck millipore,默克密理博,MABE146,Anti-5-methylcytosine Antibody, clone 33D3
产品名称：Anti-5-methylcytosine Antibody, clone 33D3
产品型号：MABE146
Use Anti-5-methylcytosine Antibody, clone 33D3 (mouse monoclonal antibody) validated in DB, IF, SB, IHC(P), Flow Cytometry, MeDIP to detect 5-methylcytosine also known as methylcytosine, methylcytidin More>>
merck millipore,默克密理博,MABE146,Anti-5-methylcytosine Antibody, clone 33D3
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H FC M Purified Monoclonal Antibody 描述 产品目录编号 MABE146 Replaces MABE527 描述 Anti-5-methylcytosine Antibody, clone 33D3 Alternate Names - methylcytidine
- methylcytosine
背景信息 5-Methylcytosine is a modified base found in the DNA of higher eukaryotes. Methylation of DNA is known to be involved in the control of gene expression and is mediated by a class of enzymes known as DNA methyltransferases (DNMT’s). Appropriate cytosine methylation is essential for normal development and maintenance of mammalian cells. Alternations in DNA methylation patterns is often associated with cancers with the turmor DNA being hypomethylated compared to DNA from normal tissues. 产品信息 格式 Purified 控制 - Methylated and unmethylated BRCA1
演示 Purified mouse monoclonal IgG1λ in buffer containing PBS without preservative. 应用 应用 Use Anti-5-methylcytosine Antibody, clone 33D3 (mouse monoclonal antibody) validated in DB, IF, SB, IHC(P), Flow Cytometry, MeDIP to detect 5-methylcytosine also known as methylcytosine, methylcytidine. 主要应用 - Flow Cytometry
应用说明 IF
Habib, M., et al. (1999). Exp Cell Res. 249:46-53
IHC-P
Hernadez-Blazquez, F.J., et al. (2000). Gut. 47:689-693
Flow Cytometry
Reynaud, C.C., et al. (1992). Cancer Lett. 61(3):255-262
MeDIP
Keshet, I., et al. (2006). Nat Genet. 38(2):149-153生物信息 免疫原品种 Ovalbumin-conjugated 5-methylcytosine 克隆 33D3 宿主 Mouse 特异性 This antibody detects 5-Methylcytosine, but not unmethylated cytosine. 同种型 IgG1λ 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human. Predicted to react with multiple species. 抗体类型 Monoclonal Antibody 纯化方法 Protein A 产品使用声明 质量保证 Evaluated by Dot Blot in methylated and unmethylated BRCA1.
Dot Blot Analysis: 1 µg/mL of this antibody detected methylcytosine in methylated and unmethylated BRCA1.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µg
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