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品种反应性 主要应用 宿主 格式 抗体类型 R, M IHC, ICC M AlexaFluor®488 Monoclonal Antibody 描述 产品目录编号 05-432A4 描述 Anti-NR1 Antibody, C Terminus, Alexa Fluor®488 Conjugate | 05-432A4 Alternate Names - NMD-R1
- Glutamate [NMDA] receptor subunit zeta-1
- N-methyl-D-aspartate receptor subunit NR1
背景信息 NR1 (NMDA1or NMDAR1, also known as GRIN1) along with the NR2 subunit forms a heterodimer that make up the NMDA receptor. The NMDA receptor (NMDAR) is characterized as a ionotropic receptor for glutamate. As the name suggests, NMDA (N-methyl D-aspartate) is an agonist for the receptor. A distinct characteriztic of the NMDA receptor is that it is both ligand-gated and voltage-dependent based on its sensitivity to magnesium. Activated NMDA receptors result in the opening of an ion channel that is nonselective to cations. The result is the flow of Na+ and small amounts of Ca2+ ions into the cell and K+ out of the cell. Calcium flux by the NMDARs has been implicated in synaptic plasticity, a mechanism in the cell for learning and memory. 产品信息 格式 AlexaFluor®488 控制 - Mouse adult brain tissue
演示 Purified mouse monoclonal IgG conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 主要应用 - Immunohistochemistry
- Immunocytochemistry
生物信息 免疫原品种 Recombinant protein corresponding to rat NR1. 表位 This antibody maps to a region (a.a. 834-864) common to all NR1 isoforms 宿主 Mouse 特异性 This antibody maps to a region (834-864) common to all NR1 isoforms and so should cross react with all NR1 isoforms. 同种型 IgG 品种反应性 RatMouse Species Reactivity Note Demonstrated to react with Mouse and Rat. Predicted to react with Human based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_058706
Entrez基因汇总 Subunit of NMDA-preferring ionotropic glutamate receptors; may play a role in long term potentiation [RGD]. 基因符号 - Nmdar1
- Grin1
纯化方法 Protein G Purified UniProt编号 - P35439
UniProt汇总 FUNCTION: NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.
SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein, Cell junction › synapse › postsynaptic cell membrane. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density. Note: Enriched in post-synaptic plasma membrane and post-synaptic densities.
POST-TRANSLATIONAL MODIFICATION: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity.
SIZE: 938 amino acids; 105,509 Da产品使用声明 质量保证 Evaluated by Immunohistochemistry in mouse adult brain tissue.
Immunohistochemistry Analysis: 1:100 dilution of this antibody detected NR1 in mouse adult brain tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 µL
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