merck millipore,默克密理愽
  • merck millipore,默克密理博,AB10532,Anti-GABA(A) receptor subunit gamma-2 Antibody

  • merck millipore,默克密理博,AB10532,Anti-GABA(A) receptor subunit gamma-2 Antibody

    产品名称：Anti-GABA(A) receptor subunit gamma-2 Antibody
    产品型号：AB10532
    This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.

    merck millipore,默克密理博,AB10532,Anti-GABA(A) receptor subunit gamma-2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB10532,Anti-GABA(A) receptor subunit gamma-2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    H, RWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB10532
    描述 Anti-GABA(A) receptor subunit gamma-2 Antibody
    Alternate Names
    • GABA(A) receptor subunit gamma-2
    • gamma-aminobutyric acid (GABA) A receptor, gamma 2
    • gamma-aminobutyric acid A receptor, gamma 2
    背景信息 GABA(A) receptor subunit gamma-2 is a protein belonging to a subclass of GABA receptors known as GABA (A). GABA (A) receptors are pentameric chloride channels composed of subunits belonging to different homology classes, i.e. α, β, γ, δ, θ, ε, π, and act as receptors for GABA, a crucial inhibitory neurotransmitter localized within the brain. GABA (A) gamma 2 subunit consists of 5 cysteine residues and carries the binding site for benzodiazepine. The subunit functions to promote receptor maintenance and clustering at the synapse, interacts with GABA receptor associated proteins such as GODZ and GABAWRAP, affects GABA (A) receptor conductance and kinetics, and is a contributing component to receptors participating in both phasic and tonic inhibition. Several mutations in the GABA(A) receptor subunit gamma-2 expression have been linked to epileptic syndromes that result in fibrile seizures.
    产品信息
    格式 Serum
    控制
    • PC12 cell lysate
    演示 Rabbit polyclonal serum containing 0.05% sodium azide.
    应用
    应用 This Anti-GABA(A) receptor subunit gamma-2 Antibody is validated for use in WB for the detection of GABA(A) receptor subunit gamma-2.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 GST-tagged recombinant protein corresponding to rat GABA(A) receptor subunit gamma-2.
    宿主 Rabbit
    特异性 This antibody recognizes GABA(A) receptor subunit gamma-2.
    品种反应性 HumanRat
    Species Reactivity Note Demonstrated to react with human and rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_899156
    Entrez基因汇总 Subunit of GABA receptors, which bind benzodiazepines and act as inhibitory ion channels in the brain [RGD].
    基因符号
    • GABRG2
    • GEFSP3
    • CAE2
    • ECA2
    纯化方法 Unpurified
    UniProt编号
    • P18508
    UniProt汇总 FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

    SUBUNIT STRUCTURE: Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

    SUBCELLULAR LOCATION: Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

    PTM: Palmitoylated by ZDHHC3/GODZ; which may affect presynaptic clustering and/or cell surface stability (By similarity).

    MISCELLANEOUS: This subunit carries the benzodiazepine binding site.

    SEQUENCE SIMLARITIES: Belongs to the ligand-gated ionic channel (TC 1.A.9) family. (View classification)
    产品使用声明
    质量保证 Evaluated by Western Blot in PC12 cell lysate.

    Western Blot Analysis: 1:1,000 dilution of this antibody detected GABA(A) receptor subunit gamma-2 on 10 µg of PC12 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB10532,Anti-GABA(A) receptor subunit gamma-2 Antibody

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