merck millipore,默克密理博,FCMAB382APC,Milli-Mark Anti-Thymidylate Synthase-APC Antibody, clone TS106

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	APC	Monoclonal Antibody

描述
产品目录编号	FCMAB382APC
商名	Milli-Mark
描述	Milli-Mark® Anti-Thymidylate Synthase-APC Antibody, clone TS106
Alternate Names	Thymidylate synthase
背景信息	TS (EC:2.1.1.45), a cytosolic enzyme, is a dimer of two identical monomers of about 36kDa. The enzyme provides the sole intracellular de novo source of thymidylate and plays a crucial role in DNA replication and repair. TS catalyzes the methylation of deoxyuridine monophosphate (dump) and its conversion to deoxythymidine monophosphate (dTMP). Therefore, TS is primarily active in proliferating and metabolic active cells. TS is a central target of the widely used antineoplastic agent 5-Fluorouracil (5-FU) and thus also of the Xeloda, which is enzymatically activated to 5-FU. TS is inactivated by a covalent complex formation with 5-FdUMP and methylenetetrahydrofolate. Literature indicates that expression of TS is associated with response to 5-fluorouracil (5-FU) in human breast, colorectal, gastric, head, and neck carcinomas with low TS expression predicting better response to 5-FU and survival. Antibody recognizes a 36 kDa protein identified as Thymidylate Synthase [TS], which is a target for the fluoropyrimidine group of antineoplastic drugs used to treat solid tumors. Expression of TS is associated with response to 5-fluorouracil (5-FU) in human breast, colorectal, gastric, head, and neck carcinomas.

产品信息
格式	APC
控制	A431 cells
演示	Purified mouse monoclonal IgG1 conjugated to APC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Milli-Mark Anti-Thymidylate Synthase-APC Antibody, clone TS106 is an antibody against Milli-Mark Thymidylate Synthase-APC for use in Flow Cytometry.
主要应用	Flow Cytometry

生物信息
免疫原品种	Recombinant Thymidylate Synthase.
克隆	TS106
宿主	Mouse
同种型	IgG1
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_001062.1
基因符号	EC 2.1.1.45 TYMS TS Tsase TMS HsT422 MGC88736
纯化方法	Protein A purified
UniProt编号	P04818

产品使用声明
质量保证	Evaluated by flow cytometry using A431 cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB382APC,Milli-Mark Anti-Thymidylate Synthase-APC Antibody, clone TS106

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