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  • merck millipore,默克密理博,07-264,Anti-PKC ζ Antibody

  • merck millipore,默克密理博,07-264,Anti-PKC ζ Antibody

    产品名称：Anti-PKC ζ Antibody
    产品型号：07-264
    Detect PKC ζ using this Anti-PKC ζ Antibody validated for use in WB.

    merck millipore,默克密理博,07-264,Anti-PKC ζ Antibody

  • 产品介绍
  • merck millipore,默克密理博,07-264,Anti-PKC ζ Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 07-264
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-PKC ζ Antibody
    产品信息
    格式 Serum
    演示 antiserum containing 23% glycerol and 0.05% sodium azide
    应用
    应用 Detect PKC ζ using this Anti-PKC ζ Antibody validated for use in WB.
    主要应用
    • Western Blotting
    生物信息
    免疫原品种 peptide corresponding to the C-terminal amino acids 577-592 (C-GFEYINPLLLSAEESV) of rat PKC-zeta
    宿主 Rabbit
    特异性 PKC zeta
    同种型 IgG
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_002744
    Entrez基因汇总 Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms.
    基因符号
    • OTTHUMP00000044160
    • PRKCZ
    • nPKC-zeta
    • PKC2
    纯化方法 Antiserum
    UniProt编号
    • Q05513
    UniProt汇总 FUNCTION: SwissProt: Q05513 # PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. Subunit of a quaternary complex that plays a central role in epithelial cell polarization.
    SIZE: 592 amino acids; 67660 Da
    SUBUNIT: Forms a ternary complex with SQSTM1 and KCNAB2. Forms another ternary complex with SQSTM1 and GABRR3. Forms a complex with SQSTM1 and MAP2K5 (By similarity). Interacts with PARD6A, PARD6B, PARD6G and SQSTM1. Part of a complex with PARD3, PARD6A or PARD6B or PARD6G and CDC42 or RAC1. Interacts with CENTA1. Forms a ternary complex composed of SQSTM1 and PAWR. Interacts directly with SQSTM1 (Probable). Interacts with IKBKB.
    SUBCELLULAR LOCATION: Cytoplasm. Endosome. Note=In the retina, localizes in the terminals of the rod bipolar cells (By similarity). Associates with endosomes.
    TISSUE SPECIFICITY: Expressed in brain, and to a lesser extent in lung, kidney and testis.
    DOMAIN: SwissProt: Q05513 The OPR domain mediates mutually exclusive interactions with SQSTM1 and PARD6B. & The C1 domain does not bind the diacylglycerol (DAG).
    SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 OPR domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on RIPA lysates from human A431 cells
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µL

    merck millipore,默克密理博,07-264,Anti-PKC ζ Antibody

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