merck millipore,默克密理博,FCMAB285F,Milli-Mark™ Anti-Achaete Scute homolog 2 Antibody, clone 7E2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	FC	M	FITC	Monoclonal Antibody

描述
产品目录编号	FCMAB285F
商名	Milli-Mark
描述	Milli-Mark™ Anti-Achaete Scute homolog 2 Antibody, clone 7E2
Alternate Names	mammalian achaete/scute homologue 2 achaete-scute complex (Drosophila) homolog-like 2 achaete-scute complex homolog 2 (Drosophila) achaete-scute complex homolog-like 2 achaete-scute complex-like 2 achaete-scute complex-like 2 (Drosophila)
背景信息	Achaete Scute homolog 2 (also known as mammalian aschaete-scute homolog 2 or Mash2) is a nuclear protein expressed specifically in the extravillous trophoblasts of developing placenta. Placental development involves control by the basic helix-loop-helix transcription factor Achaete Scute homolog 2, which may regulate HIF (hypoxia) in the formation of spongiotrophoblasts. Targeted mutagenesis of Achaete Scute homolog 2 yielded loss of function results in embryonic lethality at midgestation due to placental failure associated with a lack of spongiotrophoblasts and reduced labyrinthine trophoblast layers. In addition to healthy placental development, Achaete Scute proteins may also be involved in the determination of neuronal precursors in the central and peripheral nervous systems. Achaete Scute homolog 2 has also been implicated as a controller of intestinal stem cell fate and is essential for the maintenance of adult intestinal stem cells (Tanaka, M., et al., (1997) Dev Biol. 190(10):55-65).

产品信息
格式	FITC
控制	2102 Ep human embryonal carcinoma cells
演示	Purified mouse monoclonal IgG2bκ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.

应用
应用	Detect Achaete Scute homolog 2 using this Milli-Mark Anti-Achaete Scute homolog 2 Antibody, clone 7E2 validated for use in FC.
主要应用	Flow Cytometry

生物信息
免疫原品种	Histadine-tagged recombinant protein corresponding to human Achaete Scute homolog 2 near the C-terminus
表位	near C-terminus
克隆	7E2
宿主	Mouse
特异性	This antibody recognizes Achaete Scute homolog 2 near the C-terminus.
同种型	IgG2bκ
品种反应性	Human
Species Reactivity Note	Tested and passed on Human.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_005161
Entrez基因汇总	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基因符号	Mash2 ASCL2 ASH2 HASH2 MASH2
纯化方法	Protein G Purified
UniProt编号	Q99929
UniProt汇总	FUNCTION: AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. SUBUNIT STRUCTURE: Efficient DNA binding requires dimerization with another bHLH protein. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Expressed specifically in the extravillous trophoblasts of the developing placenta. SEQUENCE SIMILARITIES: Contains 1 basic helix-loop-helix (bHLH) domain.

产品使用声明
质量保证	Evaluated by flow cytometry using 2102 Ep human embryonal carcinoma cells
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.

包装信息
数量	100 tests

merck millipore,默克密理博,FCMAB285F,Milli-Mark™ Anti-Achaete Scute homolog 2 Antibody, clone 7E2

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