merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB129CP,Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22

  • merck millipore,默克密理博,FCMAB129CP,Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22

    产品名称：Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22
    产品型号：FCMAB129CP
    Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22 detects level of EGFR & has been published & validated for use in FC.

    merck millipore,默克密理博,FCMAB129CP,Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22

  • 产品介绍
  • merck millipore,默克密理博,FCMAB129CP,Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HFCMPerCPMonoclonal Antibody
    描述
    产品目录编号 FCMAB129CP
    商名
    • Milli-Mark
    描述 Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22
    Alternate Names
    • Receptor tyrosine-protein kinase ErbB-1 <br />avian erythroblastic leukemia viral (v-erb-b) oncogene homolog <br />cell growth inhibiting protein 40 <br />cell proliferation-inducing protein 61 <br />epidermal growth factor receptor <br />epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog) <br />epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)
    背景信息 Protein kinases are enzymes that transfer a phosphate group from a phosphate donor onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. The protein kinase family is one of the largest families of proteins in eukaryotes, classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. Epidermal Growth factor receptor (EGFR) is the prototype member of the type 1 receptor tyrosine kinases. EGFR overexpression in tumors indicates poor prognosis and is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.
    产品信息
    格式 PerCP
    控制
    • A431 cells.
    演示 Purified mouse monoclonal IgG2a conjugated to PerCP in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22 detects level of EGFR & has been published & validated for use in FC.
    主要应用
    • Flow Cytometry
    应用说明
    Working Solution Cells / test Total Reaction Volume
    5 μl 5 x 105 Cells / 95 μl PBS 100 μl
    10 μl 1 x 106 Cells / 90 μl PBS 100 μl
    生物信息
    免疫原品种 A431 membrane proteins
    表位 Unknown
    克隆 LA22
    宿主 Mouse
    特异性 Recognizes the sequence of Ala351-Asp364 of human EGF receptor, Mr 180kDa, (based on numbering without the signal peptide) (Wu et al., 1989).
    同种型 IgG2a
    品种反应性 Human
    Species Reactivity Note Tested and passed on Human. based on 100% sequence homology.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_005219.2
    Entrez基因汇总 The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq].
    基因符号
    • mENA
    • EGFR
    • ERBB1
    • ERBB
    纯化方法 Protein G purfied
    UniProt编号
    • P00533
    UniProt汇总 FUNCTION: SwissProt: P00533 # Isoform 2/truncated isoform may act as an antagonist.

    SIZE: 1210 amino acids; 134277 Da

    SUBUNIT: Binds RIPK1. CBL interacts with the autophosphorylated C- terminal tail of the EGF receptor. Part of a complex with ERBB2 and either PIK3C2A or PIK3C2B. The autophosphorylated form interacts with PIK3C2B, maybe indirectly. Interacts with PELP1.

    SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.

    TISSUE SPECIFICITY: Expressed in placenta. Isoform 2 is also expressed in ovarian cancers.

    PTM: Phosphorylation of Ser-695 is partial and occurs only if Thr- 693 is phosphorylated. & Monoubiquitinated and polyubiquitinated upon EGF stimulation; which does not affect tyrosine kinase activity or signaling capacity but may play a role in lysosomal targeting. Polyubiquitin linkage is mainly through 'Lys-63', but linkage through 'Lys-48', 'Lys-11' and 'Lys-29' also occur.DISEASE:SwissProt: P00533 # Defects in EGFR are associated with lung cancer [MIM:211980].

    SIMILARITY: SwissProt: P00533 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.

    MISCELLANEOUS: Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis, and cell proliferation
    产品使用声明
    质量保证 Evaluated by flow cytometry using A431 cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 oC protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB129CP,Milli-Mark Anti-EGFR-PerCP Antibody, clone LA22

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