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品种反应性 主要应用 宿主 格式 抗体类型 H WB R Purified Monoclonal Antibody 描述 产品目录编号 05-938 品牌系列 Upstate
商名 - Upstate
描述 Anti-ORC6 Antibody, clone 3A4 产品信息 格式 Purified 应用 应用 Anti-ORC6 Antibody, clone 3A4 is a high quality Rat Monoclonal Antibody for the detection of ORC6 & has been validated in ChIP & WB. 主要应用 - Western Blotting
生物信息 免疫原品种 Full-length human origin recognition complex 6 (ORC6). Clone 3A4. 克隆 clone 3A4 宿主 Rat 特异性 ORC6 同种型 IgG2a 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_055136
Entrez基因汇总 The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and and ORC1L are loosely associated with the core complex consisting of ORC2L, -3L, -4L and -5L. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. 基因符号 - ORC6
- ORC6L
纯化方法 Protein G purfied UniProt编号 - Q9Y5N6
UniProt汇总 FUNCTION: SwissProt: Q9Y5N6 # Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.
SIZE: 252 amino acids; 28107 Da
SUBUNIT: ORC is composed of six subunits. Interacts with DBF4 (By similarity).
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
SIMILARITY: SwissProt: Q9Y5N6 ## Belongs to the ORC6 family.产品使用声明 质量保证 Routinely evaluated by immunoblot. 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C from date of shipment 包装信息 数量 50 µL
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