merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5663P,Anti-Histamine Receptor 4 Antibody, CT

  • merck millipore,默克密理博,AB5663P,Anti-Histamine Receptor 4 Antibody, CT

    产品名称：Anti-Histamine Receptor 4 Antibody, CT
    产品型号：AB5663P
    Anti-Histamine Receptor 4 Antibody, C-terminus detects level of Histamine Receptor 4 & has been published & validated for use in ELISA & WB.

    merck millipore,默克密理博,AB5663P,Anti-Histamine Receptor 4 Antibody, CT

  • 产品介绍
  • merck millipore,默克密理博,AB5663P,Anti-Histamine Receptor 4 Antibody, CT

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HWB, ELISARbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5663P
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Histamine Receptor 4 Antibody, CT
    Alternate Names
    • H4R
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS with 0.1% BSA.
    应用
    应用 Anti-Histamine Receptor 4 Antibody, C-terminus detects level of Histamine Receptor 4 & has been published & validated for use in ELISA & WB.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Western blot: 1-10 μg/mL using ECL.

    ELISA: 1:10,000-1:100,000 using 50-100 ng control peptide per well (Catalog number AG217).

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 A 17 amino acid peptide sequence within the cytoplasmic, C-terminus of human HR4 (Oda et al. 2000; Nakamura et al. 2000).
    表位 C-terminus
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes human Histamine Receptor 4 (HR4). The immunogen shows no significant sequence homology with other histamine receptors.
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_021624.2
    Entrez基因汇总 Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H4 belongs to the family 1 of G protein-coupled receptors and has the highest homology to histamine receptor H3 among known G protein-coupled receptors.
    基因符号
    • BG26
    • HRH4
    • H4R
    • MGC133027
    • GPCR105
    • HH4R
    • GPRv53
    • H4
    • AXOR35
    • SP9144
    UniProt编号
    • Q9H3N8
    UniProt汇总 FUNCTION: SwissProt: Q9H3N8 # The H4 subclass of histamine receptors could mediate the histamine signals in peripheral tissues. Displays a significant level of constitutive activity (spontaneous activity in the absence of agonist).
    SIZE: 390 amino acids; 44496 Da
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    TISSUE SPECIFICITY: Expressed primarily in the bone marrow and eosinophils. Shows preferential distribution in cells of immunological relevance such as T-cells, dendritic cells, monocytes, mast cells, neutrophils. Also expressed in a wide variety of peripheral tissues, including the heart, kidney, liver, lung, pancreas, skeletal muscle, prostate, small intestine, spleen, fetal liver and lymph node.
    SIMILARITY: SwissProt: Q9H3N8 ## Belongs to the G-protein coupled receptor 1 family.
    MISCELLANEOUS: Does not bind diphenhydramine, loratadine, ranitidine, cimetidine and chlorpheniramine. Shows modest affinity for dimaprit, impromidine, clobenpropit, thioperamide, burimamide clozapine, immepip and imetit. The order of inhibitory activity was imetit > clobenpropit > burimamide > thioperamide. Clobenpropit behaves as a partial agonist, dimaprit and impromidine show some agonist activity while clozapine behaves as a full agonist. Thioperamide shows inverse agonism (enhances cAMP activity). The order of inhibitory activity of histamine derivatives was Histamine > N-alpha-methylhistamine > R(-)-alpha- methylhistamine > S(+)-alpha-methylhistamine. Both N-alpha- methylhistamine > R(-)-alpha-methylhistamine behave as full agonists.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB5663P,Anti-Histamine Receptor 4 Antibody, CT

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