merck millipore,默克密理愽
  • merck millipore,默克密理博,AB1504,Anti-Glutamate receptor 1 Antibody

  • merck millipore,默克密理博,AB1504,Anti-Glutamate receptor 1 Antibody

    产品名称：Anti-Glutamate receptor 1 Antibody
    产品型号：AB1504
    This Anti-Glutamate receptor 1 Antibody is validated for use in WB, IH(P), IP for the detection of Glutamate receptor 1.

    merck millipore,默克密理博,AB1504,Anti-Glutamate receptor 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB1504,Anti-Glutamate receptor 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Eq, R, M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB1504
    描述 Anti-Glutamate receptor 1 Antibody
    Alternate Names
    • glutamate receptor, ionotropic, AMPA 1
    • AMPA 1
    • AMPA-selective glutamate receptor 1
    • Glutamate receptor ionotropic, AMPA 1
    背景信息 Glutamate receptors (GluRs) can be categorized as ionotropic or metabotropic and subcatergorized by their agonist preferences (NMDA, AMPA or Kainic acid). There are four types of AMPA selective GluR subunits (GluR1, GluR2, GluR3 and GluR4). Tetrameric or pentameric combinations of different subunits contributes to the functional diversity of AMPA receptors. In general, AMPA receptors mediate fast synaptic current at most excitatory synapses, with stoichiometry characterized by subtype composition. GluR1 is believed to mediate calcium influx, and has a vital function in synaptic plasticity related to learning. Reduction in GluR1 has been caused by FMR1 gene mutation and contributes to fragile X syndrome. Changes in expression of GluR1 receptors on dopamine neurons have been correlated with sensitization of drugs of abuse.
    产品信息
    格式 Affinity Purified
    控制
    • Mouse brain lysate
    演示 Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Glutamate receptor 1 Antibody is validated for use in WB, IH(P), IP for the detection of Glutamate receptor 1.
    主要应用
    • Western Blotting
    应用说明 Immunohistochemistry Analysis: 1:300 dilution of this antibody has been shown to detect Glutamate receptor 1 (GluR1) in rat brain tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Glutamate receptor 1 at the cytoplasmic domain.
    表位 Cytoplasmic domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Glutamate receptor 1 at the cytoplasmic domain.
    品种反应性 HorseRatMouseHuman
    Species Reactivity Note Demonstrated to react with human, mouse, and rat. Predicted to react with equine and platypus based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_000818.2
    Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
    基因符号
    • GLURA
    • HBGR1
    • GluR-1
    • GRIA1
    • GluR-K1
    • GluR-A
    • GLUH1
    • GLUR1
    纯化方法 Affinity Purfied
    UniProt编号
    • P42261
    UniProt汇总 FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

    >SIZE: 906 amino acids; 101506 Da

    SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 and RASGRF2 (By similarity).

    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Interaction with CACNG2 promotes cell surface expression (By similarity).

    TISSUE SPECIFICITY: Widely expressed in brain.

    PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).

    SIMILARITY: Belongs to the glutamate-gated ion channel (TC 1.A.10) family.

    MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.
    产品使用声明
    质量保证 Evaluated by Western Blot in mouse brain lysate.

    Western Blot Analysis: 1:1000 dilution of this antibody detected Glutamate receptor 1 (GluR1) on 10 µg of mouse brain lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,AB1504,Anti-Glutamate receptor 1 Antibody

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