merck millipore,默克密理愽
  • merck millipore,默克密理博,559285,RSK Inhibitor, SL0101

  • merck millipore,默克密理博,559285,RSK Inhibitor, SL0101

    产品名称：RSK Inhibitor, SL0101
    产品型号：559285
    The RSK Inhibitor, SL0101 controls the biological activity of RSK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,559285,RSK Inhibitor, SL0101

  • 产品介绍
  • merck millipore,默克密理博,559285,RSK Inhibitor, SL0101

    重要规格表

    经验配方
    C₂₅H₂₄O₁₂
    描述
    概述 A cell-permeable Kaempferol (Cat. No. 420345) glycoside that targets the the N-terminal kinase domain of p90 ribosomal S6 kinase and inhibits RSK kinase activity (IC50 = 89 nM with 10 µM ATP) in a selective, reversible, and ATP-competitive (Ki = 1 µM) manner. Shown to inhibit the proliferation of MCF-7, but not the normal breast cell line MCF-10A, and specifically block PDB-induced cellular phosphorylation of RSK substrate p140, but not that of RSK or RSK upstream kinases even at concentrations as high as 100 µM. Also available as a 10 mM solution in DMSO (Cat. No. 559292).
    产品目录编号 559285
    品牌系列 Calbiochem®
    同义词 Kaempferol-3-O-(3ʹʹ,4ʹʹ-di-O-acetyl-α-L-rhamnopyranoside), p90 Ribosomal S6 Kinase Inhibitor, SL0101
    参考
    参考 Smith, J.A., et al. 2007. Bioorg. Med. Chem. 15, 5018.
    Smith, J.A., et al. 2006. Bioorg. Med. Chem. 14, 6043.
    Xu, Y.M., et al. 2006. Bioorg. Med. Chem. 14, 3974.
    Maloney, D.J. and Hecht, S.M., 2005. Org. Lett. 7, 1097.
    Smith, J.A., et al. 2005. Cancer Res. 65, 1027.
    产品信息
    形式 Yellow solid
    Hill配方 C₂₅H₂₄O₁₂
    化学配方 C₂₅H₂₄O₁₂
    Molar Mass 516.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,559285,RSK Inhibitor, SL0101

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