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  • merck millipore,默克密理博,EZHMWA-64K,Human High Molecular Weight (HMW) Adiponectin ELISA

  • merck millipore,默克密理博,EZHMWA-64K,Human High Molecular Weight (HMW) Adiponectin ELISA

    产品名称：Human High Molecular Weight (HMW) Adiponectin ELISA
    产品型号：EZHMWA-64K
    This Human High Molecular Weight (HMW) Adiponectin ELISA is used to measure & quantify Adiponectin levels in Metabolism & Endocrine research.

    merck millipore,默克密理博,EZHMWA-64K,Human High Molecular Weight (HMW) Adiponectin ELISA

  • 产品介绍
  • merck millipore,默克密理博,EZHMWA-64K,Human High Molecular Weight (HMW) Adiponectin ELISA

    重要规格表

    可用的分析物 品种反应性 主要应用 检测方法
    AdiponectinHELISAColorimetric, Fluorescent
    描述
    产品目录编号 EZHMWA-64K
    描述 Human High Molecular Weight (HMW) Adiponectin ELISA
    背景信息 Circulating High Molecular Weight (HMW) adiponectin is a better indicator of insulin sensitivity
    产品信息
    检测方法 ColorimetricFluorescent
    精度（%）
    • Intra-assay: 3.0 – 8.8
    • Inter-assay: 1.8 – 6.1
    应用
    应用 This Human High Molecular Weight (HMW) Adiponectin ELISA is used to measure & quantify Adiponectin levels in Metabolism & Endocrine research.
    主要应用
    • ELISA
    应用说明 Room temperature 6 hour assay including 2 hour sample pretreatment 20 µL sample size (serum or plasma)
    生物信息
    品种反应性 Human
    可用的分析物
    • Adiponectin
    Entrez基因编号
    • NM_004797.2
    Entrez基因汇总 This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes.
    基因符号
    • apM1
    • ADIPOQ
    • adiponectin
    • AdipoQ
    • apM-1
    • APM1
    • ACDC
    • GBP28
    • APM-1
    • ACRP30
    UniProt编号
    • Q15848
    UniProt汇总 FUNCTION: SwissProt: Q15848 # Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
    SIZE: 244 amino acids; 26414 Da
    SUBUNIT: Homomultimer. Forms trimers, hexamers and 12- to 18-mers. The trimers (low molecular weight complexes / LMW) are assembled via non-covalent interactions of the collagen-like domains in a triple helix and hydrophobic interactions within the globular C1q domain. Several trimers can associate to form disulfide-linked hexamers (middle molecular weight complexes / MMW) and larger complexes (higher molecular weight / HMW). The HMW-complex assembly may rely aditionnally on lysine hydroxylation and glycosylation. LMW, MMW and HMW complexes bind to HBEGF, MMW and HMW complexes bind to PDGFB, and HMW complex binds to FGF2.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: Synthesized exclusively by adipocytes and secreted into plasma.DOMAIN:SwissProt: Q15848 The C1q domain is commonly called the globular domain.
    PTM: Hydroxylated Lys-33 was not identified in PubMed:16497731, probably due to poor representation of the N-terminal peptide in mass fingerprinting. & HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagene-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin- sensitizing activity of adiponectin in hepatocytes (By similarity). & O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. & Not N-glycosylated.
    DISEASE: SwissProt: Q15848 # Defects in ADIPOQ are the cause of adiponectin deficiency [MIM:605441]. The result is a very low concentration of plasma adiponectin. Decreased adiponectin plasma levels are associated with obesity insulin resistance, and diabetes type 2.
    SIMILARITY: Contains 1 C1q domain. & Contains 1 collagen-like domain.
    MISCELLANEOUS: Variants Arg-84 and Ser-90 show impaired formation of HMW complexes whereas variants Cys-112 and Thr-164 show impaired secretion of adiponectin in any form. & HMW-complex blood contents are higher in females than in males, are increased in males by castration and decreased again upon subsequent testosterone treatment, which blocks HMW- complex secretion (By similarity). In type 2 diabetic patients, both the ratios of HMW to total adiponectin and the degree of adiponectin glycosylation are significantly decreased as compared with healthy controls.
    准确度
    • 100–118%
    理化信息
    灵敏度
    • 0.5 ng/mL
    稀释的线性 95–106%
    标准曲线范围
    • 1.56–200 ng/mL
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 96-well strip plate

    merck millipore,默克密理博,EZHMWA-64K,Human High Molecular Weight (HMW) Adiponectin ELISA

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