merck millipore,默克密理博,ABN520,Anti-MPRIP Antibody

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merck millipore,默克密理博,ABN520,Anti-MPRIP Antibody
产品名称：Anti-MPRIP Antibody
产品型号：ABN520
Anti-MPRIP Antibody is a highly specific rabbit polyclonal antibody, that targets Myosin phosphatase Rho-interacting protein & has been tested in western blotting, IHC & Immunofluorescence.

merck millipore,默克密理博,ABN520,Anti-MPRIP Antibody

产品介绍

merck millipore,默克密理博,ABN520,Anti-MPRIP Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABN520
描述	Anti-MPRIP Antibody
Alternate Names	MPRIP Myosin phosphatase Rho-interacting protein M-RIP Rho-interacting protein 3 PIP3 p116Rip
背景信息	The protein named Myosin phosphatase Rho-interacting protein (M-RIP), or Rho-interacting protein 3 (RIP3), or p116Rip and encoded by the human gene named MPRIP or KIAA0864/MRIP/RHOIP3 is an important regulator or actin cytoskeleton interactions. In muscle and neurons MPRIP targets myosin phosphatase to the actin cytoskeleton and its interaction with phosphorylated myosin. Overexpression of MPRIP leads to disassembly of actin stress fibers in neuronal and other cells types. MPRIP though its interaction with the actin cytoskeleton modulates cell morphology, particularly in neurons and strongly structural cell types, and MPRIP appears to play a key role in the JNK signaling cascade cell motility in invasive cancer cells, thus MPRIP is a current target for anti-cancer therapy. MPRIP interacts with RHOA, ROCK, MYZAP, Syntenin-1 and other cell structure associated proteins. MPRIP co-localizes with F-actin in most cells, thus it is largely cytoplasmically localized. We offer a rabbit polyclonal Anti-MPRIP Antibody that has been validated in western blot on SH-SY5Y cell extracts and in paraffin embedded immunohistochemistry on human ovary tissue sections and in fluorescent immunocytochemistry on HeLa cells in culture.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide and 50% glycerol.

应用
应用	Anti-MPRIP Antibody is a highly specific rabbit polyclonal antibody, that targets Myosin phosphatase Rho-interacting protein & has been tested in western blotting, IHC & Immunofluorescence.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:100 dilution from a representative lot detected MPRIP in human ovary tissue. Immunofluorescence Analysis: A 1:25 dilution from a representative lot detected MPRIP in HeLa cells.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human MPRIP.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
抗体类型	Polyclonal Antibody
基因符号	RHOIP3 MPRIP KIAA0864 MRIP
纯化方法	Antigen Affinity purified
UniProt编号	Q6WCQ1

产品使用声明
质量保证	Evaluated by Western Blotting in SH-SY5Y cell lysate. Western Blotting Analysis: A 1:800 dilution of this antibody detected MPRIP in SH-SY5Y cell lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.