merck millipore,默克密理愽
  • merck millipore,默克密理博,616377,Toxin B, Clostridium difficile - Calbiochem

  • merck millipore,默克密理博,616377,Toxin B, Clostridium difficile - Calbiochem

    产品名称：Toxin B, Clostridium difficile - Calbiochem
    产品型号：616377
    A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue.

    merck millipore,默克密理博,616377,Toxin B, Clostridium difficile - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,616377,Toxin B, Clostridium difficile - Calbiochem

    重要规格表
    描述
    概述 A high molecular weight glucosyltransferase that inhibits small GTPases, such as Rho, Rac, and Cdc42, by glucosylation of a threonine residue. This results in the shutdown of signal transduction cascades, leading to depolymerization of the cytoskeleton, gene transcription of a number of stress-activated protein kinases (SAPKs), and a decrease in the synthesis of phosphatidylinositiol 4,5-bisphosphate. May also block serotonin release, and stimulate the production of phospholipases C and D. Due to its ability to affect depolymerization of the cytoskeleton, toxin B has been shown to inhibit biphasic muscle contraction. Unlike Exoenzyme C3 (Cat. No. 341208), this toxin does not require assistance to permeabilize cells.
    产品目录编号 616377
    品牌系列 Calbiochem®
    同义词 Cytotoxin
    参考
    参考 Mackay, D.J. and Hall, A. 1998. J. Biol. Chem. 273, 20685.
    Prepens, U., et al. 1996. J. Biol. Chem. 271, 7324.
    Schmidt, M., et al. 1996. Eur. J. Biochem. 240, 707.
    Wilkins, T.D. and Lyerly, D.M. 1996. Trends Microbiol. 4, 49.
    产品信息
    具有ATP竞争性 N
    形式 Lyophilized
    配方 Lyophilized from 50 mM Tris, 50 mM NaCl, 0.1% trehalose, pH 7.5.
    Molar Mass 270000
    可逆 N
    生物信息
    生物活性 Cytotoxic as determined in a cell rounding assay using human foreskin cells.
    主靶 Small GTPases, such as Rho, Rac, and Cdc42
    纯度 major band at >200 kDa
    理化信息
    细胞可渗透 N
    溶解度 Sterile dH₂O
    GHS安全信息
    RTECS XW5807300
    安全信息
    R相 R: 36/37/38

    Irritating to eyes, respiratory system and skin.
    S相 S: 36-26

    Wear suitable protective clothing.
    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    无需冷冻 Yes
    特殊指南 Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 2 weeks at 4°C. Toxin B activity will decrease after 2 weeks at 4°C following reconstitution.
    加拿大出口规定 Due to the country and/or U.S. state of origin of the animal material used in this product, this product may not be exported to Canada.

    merck millipore,默克密理博,616377,Toxin B, Clostridium difficile - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,MAB8743,Anti-Japanese Encephalitis Antibody, clone 6B4A-10
下一件merck millipore产品：merck millipore,默克密理博,ECM542,ECM Cell Culture Optimization Array (Colorimetric, 48-Wells)


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