merck millipore,默克密理愽
  • merck millipore,默克密理博,ABN45,Anti-Myelin Regulatory Factor (MRF) Antibody

  • merck millipore,默克密理博,ABN45,Anti-Myelin Regulatory Factor (MRF) Antibody

    产品名称：Anti-Myelin Regulatory Factor (MRF) Antibody
    产品型号：ABN45
    This Anti-Myelin Regulatory Factor (MRF) Antibody is validated for use in western blotting & IHC for the detection of Myelin Regulatory Factor (MRF).

    merck millipore,默克密理博,ABN45,Anti-Myelin Regulatory Factor (MRF) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABN45,Anti-Myelin Regulatory Factor (MRF) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HIHC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABN45
    描述 Anti-Myelin Regulatory Factor (MRF) Antibody
    Alternate Names
    • Myelin regulatory factor, C-terminal
    • Myelin regulatory factor
    • Myelin gene regulatory factor
    • Myelin regulatory factor, N-terminal
    背景信息 Myelin Regulatory Factor (MRF), also known as Myelin regulatory factor, MYRF, and encoded by the gene MYRF/C11orf9/KIAA0954/MRF, is an interesting protein that gets cleaved into two chains. The N terminal component specifically activates transcription of myelin gene in the CNS oligodendrocytes and pre-oligodendrocytes. The C-terminal portion, which is remains membrane bound, appears to play no role in gene induction but its complete role is still being discovered. The N-terminal portion of MRF activates MBP, MOG, MAG, and PLP among other genes, but it is not required for oligodendrocyte differentiation but is required for the maintenance of myelin in the adult. MRF whole factor is localized to the endoplasmic reticulum. The cleaved N terminal portion translocates to the nucleus and the C-terminal portion remains in the endoplasmic reticulum. Interestingly MRF can be found expressed outside of oligodendrocytes and oligo precursors in the brain including regions such as the lung, basal ganglion and liver.
    产品信息
    格式 Affinity Purified
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 This Anti-Myelin Regulatory Factor (MRF) Antibody is validated for use in western blotting & IHC for the detection of Myelin Regulatory Factor (MRF).
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Western Blotting Analysis: 1.0 µg/mL from a representative lot detected Myelin Regulatory Factor (MRF) in 10 µg of ARPE19 cell lysate.
    Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Myelin Regulatory Factor (MRF) in human cerebral cortex, human retina, and human cerebellum tissue.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of human Myelin Regulatory Factor (MRF).
    表位 cytoplasmic domain, N-terminal chain
    浓缩 1.0 mg/mL
    宿主 Rabbit
    品种反应性 MouseHuman
    Species Reactivity Note Human, Mouse. Predicted to react with Rat, Hamster, Horse, Monkey based on 100% sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_037411
    基因符号
    • MRF
    • MYRF
    • C11orf9
    • KIAA0954
    纯化方法 Affinity purified
    UniProt编号
    • Q9Y2G1
    产品使用声明
    质量保证 Evaluated by Western Blotting in mouse brain tissue lysate.

    Western Blotting Analysis: 1.0 µg/mL of this antibody detected Myelin Regulatory Factor (MRF) in 10 µg of mouse brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABN45,Anti-Myelin Regulatory Factor (MRF) Antibody

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