merck millipore,默克密理愽
  • merck millipore,默克密理博,197330,Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

  • merck millipore,默克密理博,197330,Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

    产品名称：Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem
    产品型号：197330
    The Bcl-2 Inhibitor, also referenced under CAS 383860-03-5, controls the biological activity of Bcl-2. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

    merck millipore,默克密理博,197330,Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,197330,Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₆N₂O₄383860-03-5
    描述
    概述 Contains mixture of two tautomers (A and B). A potent, cell-permeable, Bcl-2 inhibitor that competes with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro (IC50 = 10 µM and 7 µM, respectively). Reduces cell viability and growth in the HL-60 cell line with high Bcl-2 expression (IC50 = 4 µM). Also induces apoptosis in a dose-dependent manner in cancer cells exhibiting high Bcl-2 expression with little effect on cancer cells with low Bcl-2 expression.
    产品目录编号 197330
    品牌系列 Calbiochem®
    同义词 2,9-Dimethoxy-11,12-dihydrodibenzo[c,g][1,2]-diazocine 5,6-dioxide (A) and 5,5ʹ-Dimethoxy-2,2ʹ-dinitrosobenzyl (B)
    参考
    参考 Enyedy, I.J., et al. 2001. J. Med. Chem. 44, 4313.
    产品信息
    CAS号 383860-03-5
    形式 Green solid
    Hill配方 C₁₆H₁₆N₂O₄
    化学配方 C₁₆H₁₆N₂O₄
    Molar Mass 300.3
    可逆 N
    结构配方图像
    生物信息
    主靶 Bcl-2
    主靶IC50 10 µM and 7 µM for competing with Bak BH3 peptide for binding to Bcl-2 and Bcl-xL in vitro, respectively; 4 µM for reducing cell viability and growth in the HL-60 cell line with high Bcl-2 expression
    纯度 ≥97% by TLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution aliquot and freeze under inert gas (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,197330,Bcl-2 Inhibitor - CAS 383860-03-5 - Calbiochem

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