merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5935,Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40

  • merck millipore,默克密理博,AB5935,Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40

    产品名称：Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40
    产品型号：AB5935
    Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40 detects level of Tyrosine Hydroxylase & has been published & validated for use in IC, IH & WB.

    merck millipore,默克密理博,AB5935,Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40

  • 产品介绍
  • merck millipore,默克密理博,AB5935,Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    Av, R, M, HWB, ICC, IHCRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5935
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40
    Alternate Names
    • Tyrosine Monooxygenase
    背景信息 Tyrosine hydroxylase plays an important role in the physiology of adrenergic neurons. It is the first and rate-limiting enzyme involved in the biosynthesis of the catecholamines Dopamine and Norepinephrine from tyrosine. TH is, therefore, a useful marker for dopaminergic and noradrenergic neurons. The enzymatic activity of TH requires ferrous ions as cofactors and is believed to be regulated by phosphorylation. At least four isoforms of human TH have been identified which result from alternative splicing.
    产品信息
    格式 Affinity Purified
    控制
    • POSITIVE CONTROL: brain (sympathetic nerve terminals) and adrenal glands.
    演示 Purified rabbit polyclonal liquid in buffer containing 10mM Hepes, pH 7.5, 150mM NaCl, 100 µg/mL BSA, and 50% glycerol.
    应用
    应用 Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40 detects level of Tyrosine Hydroxylase & has been published & validated for use in IC, IH & WB.
    主要应用
    • Western Blotting
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunohistochemistry:
    A 1:1,000 dilution of a previous lot was used in IH.

    Immunocytochemistry:
    A 1:1,000 dilution of a previous lot was used in IC.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from the phosphoSer40 of rat Tyrosine Hydroxylase.
    表位 phospho-Ser40
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Tyrosine Hydroxylase, phosphoSer40. The antibody recognizes a protein of 60 kDa corresponding to TH phosphorylated at Ser40. Depending on brain region being studied, protein loads and detection methods used some higher molecular weight bands may be detected.
    品种反应性 AvianRatMouseHuman
    Species Reactivity Note Rat and mouse. It is expected that the antibody will also react with human, porcine, quail and non-human primates due to sequence homology (100%). Other species have not been tested.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000360.3
    Entrez基因汇总 Tyrosine hydroxylase is involved in the conversion of tyrosine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.
    基因符号
    • EC 1.14.16.2
    • TH
    • TYH
    修改
    • Phosphorylation
    纯化方法 Immunoaffinity purified
    UniProt编号
    • P07101
    UniProt汇总 FUNCTION: SwissProt: P07101 # Plays an important role in the physiology of adrenergic neurons.
    COFACTOR: Fe(2+) ion.
    SIZE: 528 amino acids; 58524 Da
    TISSUE SPECIFICITY: Mainly expressed in the brain and adrenal glands.
    DISEASE: SwissProt: P07101 # Defects in TH are the cause of autosomal recessive Segawa syndrome [MIM:605407]; also known as DOPA-responsive dystonia. Typically, it begins in childhood or adolescence with progressive difficulty in walking and, in some cases, spasticity. Some cases present with parkinsonian symptoms in infancy and are referred to as autosomal recessive infantile parkinsonism.
    SIMILARITY: SwissProt: P07101 ## Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.
    产品使用声明
    质量保证 Routinely evaluated by Western Blot on PC12 lysates.

    Western Blot Analysis:
    1:500 dilution of this lot detected TYROSINE HYDROX PSER40 on 10 μg of PC12 lysates.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 6 months at -20°C in undiluted from date of receipt.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5935,Anti-Tyrosine Hydroxylase Antibody, phosphoSer 40

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