merck millipore,默克密理愽
  • merck millipore,默克密理博,361565,GSK3β Inhibitor XIX, IM-12 - Calbiochem

  • merck millipore,默克密理博,361565,GSK3β Inhibitor XIX, IM-12 - Calbiochem

    产品名称：GSK3β Inhibitor XIX, IM-12 - Calbiochem
    产品型号：361565
    The GSK3β Inhibitor XIX, IM-12 controls the biological activity of GSK3β. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,361565,GSK3β Inhibitor XIX, IM-12 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,361565,GSK3β Inhibitor XIX, IM-12 - Calbiochem

    重要规格表

    经验配方
    C₂₂H₂₀FN₃O₂
    描述
    概述 A cell-permeable indolylmaleimide derivative and SB-216763 analog that acts as a GSK-3β inhibitor, with an IC50 of 53 nM in an in vitro binding assay, compared with 92 nM for SB-216763 in the same assay condition, and reduces GSK-3β activity to 27% in an enzymatic assay at 3 µM concentration. It is shown to attenuate hNPC (human neural progenitor cells) cell proliferation, and enrich β-catenin around the nucleus of ST14 cells in the same extent of SB-216763. Furthermore, it can mimic the effect of stabilized β-catenin, up-regulates TCF-activity in a luciferase reporter gene assay, and enhances human progenitor cell differentiation.
    产品目录编号 361565
    品牌系列 Calbiochem®
    同义词 IM-12
    参考
    参考 Schmole, AC., et al. 2010. Bioorg. Med. Chem. 18, 6785.
    产品信息
    形式 Orange yellow powder
    Hill配方 C₂₂H₂₀FN₃O₂
    化学配方 C₂₂H₂₀FN₃O₂
    Molar Mass 377.41
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    灵敏度 DMSO
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,361565,GSK3β Inhibitor XIX, IM-12 - Calbiochem

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