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描述 产品目录编号 ECM400 品牌系列 Chemicon®
商名 - Chemicon
描述 αVβ3 Integrin Investigator Kit 概述 Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for investigators involved with the rapidly expanding field of integrin research. The alphaVbeta3 Investigator kit is designed for research focused on the alphaVbeta3 integrin.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
The significance of integrin alphaVbeta 3 as a marker of angiogenesis has been discussed in great detail. Addition of the monoclonal antibody, LM609, is known to block the interaction of the alphaVbeta 3 molecule with its ligands vitronectin, fibrinogen, von Willibrand factor, and CD31/PECAM-1. [Cheresh, D.A., PNAS USA 84: 6471-75].
Chemicon offers the Integrin alphaVbeta 3 Investigator Kit for initial studies of alphaVbeta 3 interactions. All kit reagents are also available in larger catalog or in bulk sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.产品信息 部件 - alphaVbeta3 Purified Integrin Protein (Part No. CC1018-10 ) - 1 tube, 10 μg.
- alphaV Rabbit Polyclonal Antibody (Part No. AB1930-20) - 1 tube, 20 μL.
- beta3 Rabbit Polyclonal Antibody (Part No. AB1932-20) - 1 tube, 20 μL.
- alphaVbeta3 Mouse Monoclonal Antibody (Part No. MAB1976Z-20) - 1 tube, 20 μg. Note: This antibody does not work on mouse
演示 The alphaVbeta3 Integrin Investigator Kit contains antibodies to alphaVbeta3 (20 μg), alphaV (20 μL), beta3 (20 μL), and purified functionally active alphaVbeta3 protein (10 μg). 应用 主要应用 - Immunocytochemistry
生物信息 品种反应性 MouseHuman Entrez基因编号 - NM_002210.2
Entrez基因汇总 ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; 'ITGB1', 'ITGB3', 'ITGB5', 'ITGB6', and 'ITGB8'), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. 基因符号 - MSK8
- ITGAV
- CD51
- DKFZp686A08142
- VNRA
UniProt编号 - P06756
UniProt汇总 FUNCTION: SwissProt: P06756 # The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and von Willebrand factor. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
SIZE: 1048 amino acids; 116038 Da
SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SIMILARITY: SwissProt: P06756 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Antibodies in kit should be stored at -20°C.
Purified alphaVbeta3 protein must be stored at -70°C.
Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vials on a hard surface before opening or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid entrapped in the container's cap during shipment.包装信息 数量 1 kit
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