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  • merck millipore,默克密理博,CC1052,Human Integrin α5β1 Protein, Triton X-100 Formulation

  • merck millipore,默克密理博,CC1052,Human Integrin α5β1 Protein, Triton X-100 Formulation

    产品名称：Human Integrin α5β1 Protein, Triton X-100 Formulation
    产品型号：CC1052


    merck millipore,默克密理博,CC1052,Human Integrin α5β1 Protein, Triton X-100 Formulation

  • 产品介绍
  • merck millipore,默克密理博,CC1052,Human Integrin α5β1 Protein, Triton X-100 Formulation

    描述
    产品目录编号 CC1052
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Human Integrin α5β1 Protein, Triton X-100 Formulation
    概述 Integrin a5/b1 purified from smooth muscle and placental tissue under nondenaturing conditions by affinity chromatography on fibronectin-Sepharose™ (Belkin, 1990).



    Two main protein bands corresponding to a5 (145 kD) and beta1 (120 kD) subunits are seen in silver stained 7.5%

    polyacrylamide gels under nonreduced conditions. Minor protein band at the 210 kD corresponding to beta1 subunit disulfide dimmer, which is formed during electrophoresis and disappears after reduction.
    Alternate Names
    • VLA-5
    产品信息
    演示 Purified protein in 20 mM Tris-HCl, pH 7.5, 150 mM NaCl, 2 mM MgCl2 containing 0.2% Triton X-100. No preservatives. Source material for the enclosed purified human proteins, Integrin alpha5beta1, has been tested for antibodies to HIV, HCV, and HbsAg and found to be negative by an approved test.
    应用
    主要应用
    • Positive Control
    应用说明 Electrophoresis and Immunoblotting control. Due to the existance of reduction sensitive sites within the integrin subunits, it is recommended that gels be run under non-reducing conditions for best results. Under non-reducing conditions, the alpha5 subunit will migrate at 155 kDa while the beta1 subunit will migrate at 110 kDa.

    Function: Liposomes containing Integrin alpha5/beta1 adhere to surfaces coated with fibronectin in an RGD-dependent fashion.
    生物信息
    纯度 Nonreduced SDS-PAGE of 15 mg on 5-15% polyacrylamide slab gel and staining with Coomassie shows only two main bands at 110 kDa (beta1 subunit) and 155 kDa (alpha5 subunit). A weak band at 205 kDa is due to dimerization of the b1 subunit (Belkin et al., 1996).

    CONTAMINANT(S):

    None identified.
    来源 Human smooth muscle and placental tissue.
    品种 Human
    Entrez基因编号
    • NM_002205.2
    Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
    基因符号
    • FNRA
    • ITGA5
    • VLA-5
    • CD49e
    • VLA5A
    UniProt编号
    • P08648
    UniProt汇总 FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1049 amino acids; 114536 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 25 µg

    merck millipore,默克密理博,CC1052,Human Integrin α5β1 Protein, Triton X-100 Formulation

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