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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB M Ascites Monoclonal Antibody 描述 产品目录编号 05-219 品牌系列 Upstate
商名 - Upstate
描述 Anti-Vav Antibody 产品信息 格式 Ascites 演示 ascites fluid containing 0.05% sodium azide 应用 应用 Anti-Vav Antibody is an antibody against Vav for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 GST-fusion to full length human Vav 宿主 Mouse 特异性 human and murine p95vav and p85vav 同种型 IgG 品种反应性 MouseHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_005428.2
Entrez基因汇总 The protein encoded by this proto-oncogene is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. 基因符号 - VAV
- VAV1
UniProt编号 - P15498
UniProt汇总 FUNCTION: SwissProt: P15498 # Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
SIZE: 845 amino acids; 98314 Da
SUBUNIT: May interact with CCPG1 (By similarity). Interacts with APS, DOCK2, GRB2, GRB3, DOCK2, SLA and ZNF655/VIK. Interacts with SIAH2; without leading to its degradation. Associates with BLNK, PLCG1, GRB2 and NCK1 in a B-cell antigen receptor-dependent fashion. Interacts with CBLB; which inhibits tyrosine phosphorylation and down-regulates activity. Interacts with SHB.
TISSUE SPECIFICITY: Widely expressed in hematopoietic cells but not in other cell types.
DOMAIN: SwissProt: P15498 The DH domain is involved in interaction with CCPG1 (By similarity).
PTM: Phosphorylated on tyrosine residues.
SIMILARITY: Contains 1 CH (calponin-homology) domain. & Contains 1 DH (DBL-homology) domain. & Contains 1 PH domain. & Contains 1 phorbol-ester/DAG-type zinc finger. & Contains 1 SH2 domain. & Contains 2 SH3 domains.
MISCELLANEOUS: 'Vav' stands for the sixth letter of the Hebrew alphabet.产品使用声明 质量保证 routinely evaluated on RIPA lysates of Jurkat cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µL
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下一件merck millipore产品：merck millipore,默克密理博,373227,MDM2 Inhibitor VII, MEL23 - Calbiochem
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