merck millipore,默克密理愽
  • merck millipore,默克密理博,373227,MDM2 Inhibitor VII, MEL23 - Calbiochem

  • merck millipore,默克密理博,373227,MDM2 Inhibitor VII, MEL23 - Calbiochem

    产品名称：MDM2 Inhibitor VII, MEL23 - Calbiochem
    产品型号：373227
    The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

    merck millipore,默克密理博,373227,MDM2 Inhibitor VII, MEL23 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,373227,MDM2 Inhibitor VII, MEL23 - Calbiochem

    重要规格表

    经验配方
    C₁₉H₂₂N₄O₃
    描述
    概述 A cell-permeable tetrahydro-β-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100 µM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc. = 14 µM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3 (Cat. Nos. 444143 & 444151), MEL23 does not interfere with Mdm2-p53 interaction.
    产品目录编号 373227
    品牌系列 Calbiochem®
    同义词 3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione, MDM2-MDMX E3 Ligase Inhibitor
    参考
    参考 Herman, A.G., et al. 2011. Cancer Discovery 1, 312.
    产品信息
    形式 Yellow solid
    Hill配方 C₁₉H₂₂N₄O₃
    化学配方 C₁₉H₂₂N₄O₃
    Molar Mass 354.4
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,373227,MDM2 Inhibitor VII, MEL23 - Calbiochem

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