merck millipore,默克密理博,208719,ALLN - CAS 110044-82-1

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merck millipore,默克密理博,208719,ALLN - CAS 110044-82-1 - Calbiochem
产品名称：ALLN - CAS 110044-82-1 - Calbiochem
产品型号：208719
Cell-permeable inhibitor of calpain I (Ki = 190 nM), calpain II (Ki = 220 nM), cathepsin B (Ki = 150 nM), and cathepsin L (Ki = 500 pM).

merck millipore,默克密理博,208719,ALLN - CAS 110044-82-1 - Calbiochem

产品介绍

merck millipore,默克密理博,208719,ALLN - CAS 110044-82-1 - Calbiochem

重要规格表

经验配方	CAS号
C₂₀H₃₇N₃O₄	110044-82-1

描述
概述	Cell-permeable inhibitor of calpain I (K_i= 190 nM), calpain II (K_i= 220 nM), cathepsin B (K_i= 150 nM), and cathepsin L (K_i= 500 pM). Inhibits neutral cysteine proteases and the proteasome (K_i = 6 µM). Modulates the processing of the β-amyloid precursor protein (βAPP) to β-amyloid (Aβ). Protects against neuronal damage caused by hypoxia and ischemia. Inhibits apoptosis in thymocytes and metamyelocytes. Also inhibits reovirus-induced apoptosis in L929 cells. Inhibits the proteolysis of IκB-α and IκB-β by the ubiquitin-proteasome complex. Inhibits cell cycle progression at G₁/S and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. Also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene. A 10 mM (5 mg/1.30 ml) solution of ALLN (Cat. No. 208750) in DMSO is also available.
产品目录编号	208719
品牌系列	Calbiochem®
同义词	LLNL, MG 101, Calpain Inhibitor I, Proteasome Inhibitor V

参考
参考	Debiasi, R.L., et al. 1999. J. Virol. 73, 695. Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966. Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388. Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721. Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229. Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67. Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353. Vinitsky, A., et al. 1992. Biochemistry 31, 9421. Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

参考

Debiasi, R.L., et al. 1999. J. Virol. 73, 695.
Zhang, L., et al. 1999. J. Biol. Chem. 274, 8966.
Milligan, S.A., et al. 1996. Arch. Biochem. Biophys. 335, 388.
Griscavage, J.M., et al. 1995. Biochem. Biophys. Res. Commun. 215, 721.
Squier, M.K., et al. 1994. J. Cell Physiol. 159, 229.
Rami, J., and Kreiglstein, J. 1993. Brain Res. 609, 67.
Sherwood, S.W., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 3353.
Vinitsky, A., et al. 1992. Biochemistry 31, 9421.
Sasaki, T., et al. 1990. J. Enzyme Inhib. 3, 195.

产品信息
CAS号	110044-82-1
具有ATP竞争性	N
形式	White to off-white solid
Hill配方	C₂₀H₃₇N₃O₄
化学配方	C₂₀H₃₇N₃O₄
Molar Mass	383.5
肽序列	N-Acetyl-Leu-Leu-Nle-CHO
可逆	N
结构配方图像

生物信息
主靶	Calpain-1
主靶K_i	190 nM, 220 nM, 150 nM, 500 pM, against calpain I, calpain II, cathepsin B, and cathepsin L, respectively
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH
肽序列	N-Acetyl-Leu-Leu-Nle-CHO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.