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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 CBL519 Replaces CBL519B 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD57 Antibody, clone NK-1 Alternate Names - Leu-7
- HNK-1
产品信息 格式 Purified 演示 The monoclonal is presented in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 This Anti-CD57 Antibody, clone NK-1 is validated for use in FC, IH, IH(P) for the detection of CD57. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Formalin fixed paraffin wax embedded sections
Frozen sections
Flow cytometry
Analysis of NK cell-mediated cytotoxicity
Studies of functional properties of NK cell and T cell subsets
Studies of neural tissue glycoproteins
Optimal working dilutions must be determined by the end user.生物信息 克隆 NK-1 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 The antibody reacts with a carbohydrate antigen present on a subset of peripheral blood mononuclear cells involved in the natural killer activity, which is not MHC restricted. The antigen is not present on B cells, monocytes, red blood cells or platelets but is expressed on cells in neuroectodermal tissue. It reacts with 20% of normal human peripheral blood mononuclear cells. 同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_054025.2
- NM_018644.3
Entrez基因汇总 The protein encoded by this gene is a member of the glucuronyltransferase gene family. These enzymes exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product functions as the key enzyme in a glucuronyl transfer reaction during the biosynthesis of the carbohydrate epitope HNK-1 (human natural killer-1, also known as CD57 and LEU7). Alternate transcriptional splice variants have been characterized. 基因符号 - GlcUAT-P
- CD57
- GlcAT-P
- EC 2.4.1.135
- B3GAT1
- HNK1
- Glucuronosyltransferase-P
- GLCATP
- NK-1
- HNK-1
- LEU7
UniProt编号 - Q9P2W7
UniProt汇总 FUNCTION: SwissProt: Q9P2W7 # Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo- orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl- sphingomyelin was the most effective, followed by palmitoyl- sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity).
COFACTOR: Manganese.
SIZE: 334 amino acids; 38355 Da
SUBUNIT: Homodimer (Potential).
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
TISSUE SPECIFICITY: Mainly expressed in the brain.
SIMILARITY: SwissProt: Q9P2W7 ## Belongs to the glycosyltransferase 43 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C for up to one year. 包装信息 数量 100 µg
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