merck millipore,默克密理博,575547,Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7

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Merck Millipore 默克密理愽

merck millipore,默克密理博,575547,Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem

经验配方	CAS号
C₂₅H₂₆N₂O₅	664993-53-7

描述
概述	A cell-permeable phenylcarbamoylfuran-carboxamide compound that acts as a potent, selective, and reversible inhibitor of poly(ADP-ribosyl)ation activity of tankyrase 1 and 2 (IC₅₀ = 1.9 and 0.83 µM, respectively). Exhibits high selectivity over PARP1 (IC₅₀ = 20 µM). Stabilizes and increases AXIN2 levels, thereby enhancing phosphorylation and degradation of β-catenin resulting in reduced canonical Wnt signaling (IC₅₀ = 470 nM in Wnt 3a-induced HEK293 cells transfected with ST-Luc). Shown to induce cell cycle arrest and diminish the proliferation of SW480 colorectal cancer cells (~ 5 µM). Suppresses tumor growth in tamoxifen-induced polyposis in Apc knock-out murine model (100 mg/kg, i.p.). Displays adequate human liver microsomal stability (t_1/2 = 10.1 min).
产品目录编号	575547
品牌系列	Calbiochem®
同义词	N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)methylcarbamoyl)phenyl)furan-2-carboxamide, TNKS1/2 Inhibitor IV, Wnt Pathway Inhibitor XVII

参考
参考	Waaler, J., et al. 2012. Cancer Res. 72, 2822.

生物信息
主靶	tankyrase 1 and 2
纯度	≥99% HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,575547,Tankyrase1/2 Inhibitor IV, JW55 - CAS 664993-53-7 - Calbiochem

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