merck millipore,默克密理愽
  • merck millipore,默克密理博,CBL497F,Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated

  • merck millipore,默克密理博,CBL497F,Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated

    产品名称：Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated
    产品型号：CBL497F
    Detect Integrin α5 using this Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated validated for use in FC, IH.

    merck millipore,默克密理博,CBL497F,Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated

  • 产品介绍
  • merck millipore,默克密理博,CBL497F,Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, FCMFITCMonoclonal Antibody
    描述
    产品目录编号 CBL497F
    Replaces MAB2255F
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated
    Alternate Names
    • CD49e
    产品信息
    格式 FITC
    演示 The conjugate is supplied as a 100 test/1 mL vial in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. For flow cytometry we recommend using 10μL of conjugate per test.
    应用
    应用 Detect Integrin α5 using this Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated validated for use in FC, IH.
    主要应用
    • Immunohistochemistry
    • Flow Cytometry
    应用说明 Functional studies on platelets where VLA-5 acts as a fibronectin receptor. Platelet adhesion to fibronectin is inhibited by CBL 497

    Direct immunofluorescence staining with analysis by FACS or fluorescence microscopy

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 U937 cells
    克隆 SAM-1
    宿主 Mouse
    特异性 The monoclonal antibody is directed against the CD49e antigen (GPIc or VLA-5 alpha chain), which can form distinct complexes with either the CD29 antigen (GP IIa or VLA beta chain), resulting in the VLA-5 (alpha5 beta1) complex which is expressed on human platelets. The monoclonal antibody reacts with platelets and monocytes and also weakly with T cells and granulocytes. It also reacts with various cell types of non-haemopoietic origin.

    FUSION PARTNER: SP2/0 myeloma cell line
    同种型 IgG2b
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_002205.2
    Entrez基因汇总 The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
    基因符号
    • FNRA
    • ITGA5
    • VLA-5
    • CD49e
    • VLA5A
    UniProt编号
    • P08648
    UniProt汇总 FUNCTION: SwissProt: P08648 # Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
    SIZE: 1049 amino acids; 114536 Da
    SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5. Interacts with HIV-1 Tat.
    SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
    SIMILARITY: SwissProt: P08648 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Store at +4°C protected from light. DO NOT FREEZE. For long term use and storage aliquot conjugate into small volumes and store at +4°C.
    包装信息
    数量 100 assays

    merck millipore,默克密理博,CBL497F,Anti-Integrin α5 Antibody, clone SAM-1, FITC conjugated

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