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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC M Purified Monoclonal Antibody 描述 产品目录编号 CBL475 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD1b Antibody, clone WM25 产品信息 格式 Purified 演示 The monoclonal is presented at a concentration of 100μg/1ml in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Anti-CD1b Antibody, clone WM25 is an antibody against CD1b for use in FC, IP, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
应用说明 Analysis of early stages of T cell differentiation
Immunodiagnosis of certain acute lymphoblastic leukaemias and high grade T cell non-Hodgkins lymphomas
Immunoprecipitation studies of the CD1b antigen
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Human thymocytes and splenic lymphocytes 克隆 WM25 宿主 Mouse 特异性 This antibody reacts with an epitope distinct from human thymocyte antigen - 1 (43 kDa) that is expressed on the majority of thymocytes and approximately 50% of cases of T ALL. This antibody does not stain Langerhans cells.
Antigen distribution:
Thymocytes 80 ± 10%
Granulocytes < 1%
Monocytes < 1%
B cells (E+) < 1%
T cells (E-) < 1%
Peripheral blood lymphocytes < 1%
FUSION PARTNER: NS1 myeloma cell line同种型 IgG1 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001764.2
Entrez基因汇总 This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. 基因符号 - CD1A
- CD1B
- R1
- CD1
- MGC125991
- MGC125990
UniProt编号 - P29016
UniProt汇总 FUNCTION: SwissProt: P29016 # Not known.
SIZE: 333 amino acids; 36939 Da
SUBUNIT: Associates non-covalently with beta-2-microglobulin.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
SIMILARITY: SwissProt: P29016 ## Contains 1 Ig-like (immunoglobulin-like) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 100 µg
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