merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5755,Anti-Glial Derived Neurotrophic Factor Antibody

  • merck millipore,默克密理博,AB5755,Anti-Glial Derived Neurotrophic Factor Antibody

    产品名称：Anti-Glial Derived Neurotrophic Factor Antibody
    产品型号：AB5755
    This Anti-Glial Derived Neurotrophic Factor Antibody is validated for use in ELISA, WB for the detection of Glial Derived Neurotrophic Factor.

    merck millipore,默克密理博,AB5755,Anti-Glial Derived Neurotrophic Factor Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5755,Anti-Glial Derived Neurotrophic Factor Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, ELISAChAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5755
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Glial Derived Neurotrophic Factor Antibody
    Alternate Names
    • GDNF
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
    应用
    应用 This Anti-Glial Derived Neurotrophic Factor Antibody is validated for use in ELISA, WB for the detection of Glial Derived Neurotrophic Factor.
    主要应用
    • Western Blotting
    • ELISA
    应用说明 Immunoblotting: 1:500-1:2,000

    Immunohistochemistry: not tested. It is recommended that you try the antibody at 1:50-1:500.

    ELISA: 1:500-1:2,000

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptides from human GDNF.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Chicken
    特异性 Glial Derived Neurotrophic Factor (GDNF).
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_199234.1
    • NM_000514.2
    • NM_199231.1
    Entrez基因汇总 This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. In addition to the transcript encoding GDNF, two additional alternative transcripts encoding distinct proteins, referred to as astrocyte-derived trophic factors, have also been described. Mutations in this gene may be associated with Hirschsprung disease.
    基因符号
    • ATF
    • GDNF
    • HFB1-GDNF
    • ATF1
    • ATF2
    • hGDNF
    UniProt编号
    • P39905
    UniProt汇总 FUNCTION: SwissProt: P39905 # Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.
    SIZE: 211 amino acids; 23720 Da
    SUBUNIT: Homodimer; disulfide-linked.
    SUBCELLULAR LOCATION: Secreted.
    TISSUE SPECIFICITY: In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen.
    DISEASE: SwissProt: P39905 # Defects in GDNF may be a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, defects in GDNF may be involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. & Defects in GDNF are a cause of congenital central hypoventilation syndrome (CCHS) [MIM:209880]; also known as congenital failure of autonomic control or Ondine curse. CCHS is a rare disorder characterized by abnormal control of respiration in the absence of neuromuscular or lung disease, or an identifiable brain stem lesion. A deficiency in autonomic control of respiration results in inadequate or negligible ventilatory and arousal responses to hypercapnia and hypoxemia.
    SIMILARITY: SwissProt: P39905 ## Belongs to the TGF-beta family. GDNF subfamily.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,AB5755,Anti-Glial Derived Neurotrophic Factor Antibody

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