merck millipore,默克密理愽
  • merck millipore,默克密理博,14-628M,TBK1 Protein, active, 250 µg

  • merck millipore,默克密理博,14-628M,TBK1 Protein, active, 250 µg

    产品名称：TBK1 Protein, active, 250 µg
    产品型号：14-628M
    Active, N-terminal His6-tagged, recombinant, full length, human TBK1, for use in Kinase Assays.

    merck millipore,默克密理博,14-628M,TBK1 Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-628M,TBK1 Protein, active, 250 µg

    描述
    产品目录编号 14-628M
    品牌系列 Upstate
    商名
    • Upstate
    描述 TBK1 Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant, full length, human TBK1
    应用
    应用 Active, N-terminal His6-tagged, recombinant, full length, human TBK1, for use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 expressed by baculovirus in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_013254.2
    Entrez基因汇总 The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. The protein encoded by this gene is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. For example, the protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.
    基因符号
    • FLJ11330
    • TBK1
    • T2K
    • NAK
    蛋白靶 TBK1
    纯化方法 Ni2+/NTA-agarose
    靶子系列 Misc
    UniProt编号
    • Q9UHD2
    UniProt汇总 FUNCTION: SwissProt: Q9UHD2 # Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively.
    SIZE: 729 amino acids; 83642 Da
    SUBUNIT: Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1. Interacts with AZI2. Interacts with SIKE. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between TBK1 and SIKE. Interacts with HCV NS3, a hepatitis C virus protein and with BDV P protein, a Borna disease virus protein.
    SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Ubiquitous with higher expression in testis.
    SIMILARITY: SwissProt: Q9UHD2 ## Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. IkappaB kinase subfamily. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of CK1tide (12-529)
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-628) and in bulk (cat# 14-628-K).

    merck millipore,默克密理博,14-628M,TBK1 Protein, active, 250 µg

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