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经验配方 CAS号 C₃₀H₄₈O₃ 472-15-1 描述 概述 Antitumor and anti-HIV agent. A pentacyclic triterpene that selectively inhibits human melanoma in cell culture and in animal models. Appears to act specifically on melanoma cells without affecting other types of tumors. The antitumor effects of betulinic acid appear to be associated with the induction of mitochondrial permeability transition pore that triggers apoptosis. Also acts as a potent inhibitor of Hh/Gli signaling pathway inhibitor (IC50 = 32 µM). 产品目录编号 200498 品牌系列 Calbiochem®
同义词 3β-Hydroxy-20(29)-lupaene-28-oic Acid 参考 参考 Hollis, A., et al. 2012. ChemBioChem> in press.
Arai, M.A., et al. 2008. Bioorg. Med. Chem. 18, In press.
Fulda, S., et al. 1998. J. Biol. Chem. 273, 33942.
Rieber, M. and Strasberg-Reiber, M., et al. 1998. DNA Cell. Biol. 17, 399.
Kashiwada, Y., et al. 1996. J. Med. Chem. 39, 1016.
Pisha, E., et al. 1995. Nat. Med. 1, 1046.
Recio, M.C., et al. 1995. Planta Med. 61, 9.
Fujioka, T., et al. 1994. J. Nat. Prod. 57, 243.产品信息 CAS号 472-15-1 具有ATP竞争性 N 形式 Colorless solid Hill配方 C₃₀H₄₈O₃ 化学配方 C₃₀H₄₈O₃ Molar Mass 456.7 可逆 N 结构配方图像 生物信息 主靶 Inhibits human melanoma in cell culture and in animal models 主靶IC50 32 µM inhibiting Hh/Gli signaling pathway 纯度 >97% by HPLC 理化信息 细胞可渗透 N 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 3 months at -20°C.
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