- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M IHC, ELISA, FC, WB R Purified Monoclonal Antibody 描述 产品目录编号 CBL1366 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD140a Antibody, clone APA5 Alternate Names - PDGF Receptor alpha
产品信息 格式 Purified 演示 Purified immunoglobulin in PBS, 150 mM NaCl, pH 7.2, containing 0.09% sodium azide. 应用 应用 Detect CD140a using this Anti-CD140a Antibody, clone APA5 validated for use in ELISA, FC, WB, IH. 主要应用 - Immunohistochemistry
- ELISA
- Flow Cytometry
- Western Blotting
应用说明 Flow Cytometry: <= 1 μg per 10E6 cells
ELISA
Immunohistochemistry: 10μg/mL
Blocking of Ligand Binding
Western Blotting
Optimal working dilutions must be determined by the end user.生物信息 克隆 APA5 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rat 特异性 Specifically recognizes mouse CD140a, the alpha chain of PDGF receptor. A receptor tyrosine kinase, PDGFRa forms dimers on the surface upon ligand binding and phosphorylates substrates. CD140a is expressed by embryonic tissues and mesenchymal-derived cells of the adult mouse tissues. 同种型 IgG2aκ 品种反应性 Mouse 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_006206.3
Entrez基因汇总 This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. 基因符号 - EC 2.7.10.1
- PDGFRA
- CD140a
- PDGFR2
- Rhe-PDGFRA
- PDGF-R-alpha
- CD140A
- MGC74795
UniProt编号 - P16234
UniProt汇总 FUNCTION: SwissProt: P16234 # Receptor that binds both PDGFA and PDGFB and has a tyrosine-protein kinase activity.
SIZE: 1089 amino acids; 122670 Da
SUBUNIT: Homodimer, and heterodimer with PDGFRB. Interacts with SHB (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
DISEASE: SwissProt: P16234 # A fusion of PDGFRA and FIP1L1 (FIP1L1-PDGFRA), due to an interstitial chromosomal deletion, is the cause of some cases of hypereosinophilic syndrome (HES) [MIM:607685]. HES is a rare hematologic disorder characterized by sustained overproduction of eosinophils in the bone marrow, eosinophilia, tissue infiltration and organ damage.
SIMILARITY: SwissProt: P16234 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8°C for up to 12 months from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,04-1624,Anti-Centrin Antibody, clone 20H5
下一件merck millipore产品：merck millipore,默克密理博,2006-OP,OmniPur ABTS Liquid Substrate - Calbiochem
相关产品
merck millipore,默克密理博,346003,Glucagon Receptor Antagonist II - CAS 191034-25-0 - Calbiochem
merck millipore,默克密理博,07-218,Anti-Notch1 Antibody, extracellular domain
merck millipore,默克密理博,AB707-KC,Goat Anti-Human Alpha-1-Antitrypsin (KC)
merck millipore,默克密理博,SCM083,ES2N Basal Medium
merck millipore,默克密理博,04-1624,Anti-Centrin Antibody, clone 20H5
merck millipore,默克密理博,2006-OP,OmniPur ABTS Liquid Substrate - Calbiochem
merck millipore,默克密理博,HTS093RTA,Ready-to-Assay™ FP Prostanoid Receptor Frozen Cells
merck millipore,默克密理博,07-2132,Anti-PIP5K1 gamma Antibody, (long form)
merck millipore,默克密理博,06-1044,Anti-MAVS/Cardif (CT) Antibody
merck millipore,默克密理博,05-393,Anti-p80 Ku Antibody, clone GE2.9.5