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merck millipore,默克密理博,346003,Glucagon Receptor Antagonist II - CAS 191034-25-0 - Calbiochem
产品名称：Glucagon Receptor Antagonist II - CAS 191034-25-0 - Calbiochem
产品型号：346003
The Glucagon Receptor Antagonist II, also referenced under CAS 191034-25-0, controls the biological activity of Glucagon Receptor.
merck millipore,默克密理博,346003,Glucagon Receptor Antagonist II - CAS 191034-25-0 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₄H₂₀BrClN₂O 191034-25-0 描述 概述 A cell-permeable triarylpyrrole compound that acts as a selective, non-competitive, high affinity glucagon receptor antagonist (IC50 = 3.7 nM, 63 nM, and 60 nM for inhibition of labeled glucagon binding to human, murine, and canine glucagon receptor, respectively). Exhibits diminished antagonistic properties in the presence of Mg2+ (by ≥ 20-fold) and exhibits poor affinity for the rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 µM). Does not inhibit binding of glucagon-like peptide-1 (GLP-1) to the homologous GLP-1 receptor even at concentrations as high as 10 µM. Does not affect ligand binding of a panel of other GPCRs and only weakly affects p38 kinase activity (IC50 = 1.44 µM). Potently inhibits glucagon-induced GTPγS binding to Gαs (IC50 = 158 nM) and adenylate cyclase activation in hGLUR-CHO cells (Kb = 25 nM). Shown to be orally bioavailable in both mice and rats. 产品目录编号 346003 品牌系列 Calbiochem®
同义词 2-(4-Pyridyl)-5-(4-chlorophenyl)-3-(5-bromo-2-propyloxyphenyl)pyrrole, L-168,049 参考 参考 Dallas-Yang, Q., et al. 2002. Anal. Biochem. 301, 156.
Cascieri, M.A., et al. 1999. J. Biol. Chem. 274, 8694.
de Laszlo, S.E., et al. 1999. Bioorg. Med. Chem. Lett. 9, 641.产品信息 CAS号 191034-25-0 具有ATP竞争性 N 形式 Light beige solid Hill配方 C₂₄H₂₀BrClN₂O 化学配方 C₂₄H₂₀BrClN₂O Molar Mass 467.8 可逆 N 结构配方图像 生物信息 主靶 Glucagon Receptor 主靶IC50 3.7 nM, 63 nM, and 60 nM for inhibition of labeled glucagon binding to human, murine, and canine glucagon receptor, respectively 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO or EtOH 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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