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merck millipore,默克密理博,05-393,Anti-p80 Ku Antibody, clone GE2.9.5
产品名称：Anti-p80 Ku Antibody, clone GE2.9.5
产品型号：05-393
Anti-p80 Ku Antibody, clone GE2.9.5 is a high quality Mouse Monoclonal Antibody for the detection of p80 Ku & has been validated in IP, WB, ICC.
merck millipore,默克密理博,05-393,Anti-p80 Ku Antibody, clone GE2.9.5
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-393 品牌系列 Upstate
商名 - Upstate
描述 Anti-p80 Ku Antibody, clone GE2.9.5 产品信息 格式 Purified 演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide 应用 应用 Anti-p80 Ku Antibody, clone GE2.9.5 is a high quality Mouse Monoclonal Antibody for the detection of p80 Ku & has been validated in IP, WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
生物信息 免疫原品种 T-cell protein complex containing Ku. 克隆 clone GE2.9.5 宿主 Mouse 特异性 p80 subunit of the Ku autoantigen 同种型 IgG2aκ 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_021141.2
Entrez基因汇总 The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. 基因符号 - KUB2
- XRCC5
- Ku86
- KARP-1
- NFIV
- Ku80
- TLAA
- CTC85
- CTCBF
- G22P2
- KARP1
- FLJ39089
- KU80
纯化方法 Protein G chromatography UniProt编号 - P13010
UniProt汇总 FUNCTION: SwissProt: P13010 # Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by p70. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The Ku p70/p86 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The Ku p70/p86 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. In association with NARG1, the Ku p70/p86 dimer binds to the osteocalcin promoter and activates osteocalcin expression.
SIZE: 732 amino acids; 82705 Da
SUBUNIT: Heterodimer of a 70 kDa and a 80 kDa subunit. The dimer associates in a DNA-dependent manner with PRKDC to form the DNA- dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex. The dimer also associates with NARG1, and this complex displays DNA binding activity towards the osteocalcin FGF response element (OCFRE). In addition, the 80 kDa subunit binds to the osteoblast-specific transcription factors MSX2 and RUNX2. Interacts with ELF3. May interact with APLF.
SUBCELLULAR LOCATION: Nucleus.
DOMAIN: SwissProt: P13010 The EEXXXDDL motif is required for the interaction with catalytic subunit PRKDC and its recruitment to sites of DNA damage.
PTM: Phosphorylated on serine residues. Phosphorylation by PRKDC may enhance helicase activity. & Sumoylated.DISEASE:SwissProt: P13010 # Individuals with systemic lupus erythematosus (SLE) and related disorders produce extremely large amounts of autoantibodies to p70 and p86.
SIMILARITY: Contains 1 Ku domain.产品使用声明 质量保证 routinely evaluated by immunoblot on a HeLa nuclear extract 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 2 years at -20°C 包装信息 数量 200 µg
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