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描述 产品目录编号 AG216 品牌系列 Chemicon®
商名 - Chemicon
描述 Presenilin-2, blocking peptide for AB5056 概述 Synthetic peptide from the N-terminal of human presenilin-2. 产品信息 演示 Liquid in sterile water. Contains no preservative. 应用 主要应用 - Cell Function Assay
应用说明 For use in blocking the reactivity of AB5056.
Optimal working dilution must be determined by the end user.生物信息 浓缩 1.0 mg/mL 品种 Human Entrez基因编号 - NM_012486.2
- NM_000447.2
Entrez基因汇总 Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. 基因符号 - Presenilin-2 CTF subunit].
- PSEN2
- AD5
- AD3L
- STM2
- STM-2
- AD3LP
- E5-1
- Presenilin-2
- PSNL2
- PS-2
- PS2
- AD4
- EC 3.4.23.- [Contains: Presenilin-2 NTF subunit
UniProt编号 - P49810
UniProt汇总 FUNCTION: SwissProt: P49810 # Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
SIZE: 448 amino acids; 50140 Da
SUBUNIT: Interacts with DOCK3 (By similarity). Homodimer. Component of the gamma-secretase complex, a complex composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2. Such minimal complex is sufficient for secretase activity, although other components may exist. Interacts with HERPUD1, FLNA, FLNB and PARL.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
DOMAIN: SwissProt: P49810 The PAL motif is required for normal active site conformation (By similarity).
PTM: Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. & Phosphorylated on serine residues.
DISEASE: SwissProt: P49810 # Defects in PSEN2 are the cause of Alzheimer disease type 4 (AD4) [MIM:606889, 104300]. AD is an autosomal dominant neurodegenerative disorder characterized by progressive dementia, parkinsonism, and deposition of fibrillar amyloid proteins as intraneuronal neurofibrillary tangles, extracellular amyloid plaques and vascular amyloid deposits. Early onset AD is the most severe form of the disease, with complete penetrance and an onset occurring as early as 30 years of age. The second form is late- onset AD (LOAD), with mean age of onset greater than 58 years. & Three causative genes have been identified that when mutated lead to presenile Alzheimer
DISEASE: APP (amyloid precursor protein gene), PSEN1 and PSEN2. These three genes account for half of the families with autosomal dominant presenile AD, which represent approximately 10% of the whole AD population. In addition, apolipoprotein E has been identified as a risk- modifying locus.
SIMILARITY: Belongs to the peptidase A22A family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C to -70°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles 包装信息 数量 100 µg
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