merck millipore,默克密理愽
  • merck millipore,默克密理博,529531,PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem

  • merck millipore,默克密理博,529531,PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem

    产品名称：PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem
    产品型号：529531
    The PICK1 PDZ Domain Inhibitor, FSC231 controls the biological activity of PICK1. This small molecule/inhibitor is primarily used for Neuroscience applications.

    merck millipore,默克密理博,529531,PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,529531,PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem

    重要规格表

    经验配方
    C₁₃H₁₀Cl₂N₂O₃
    描述
    概述 A cell-permeable acryloylcarbamate compound that selectively targets the PDZ (PSD-95/Discs-large/ZO-1 homology) domain of PICK1 (protein interacting with C kinase 1), but not those of PSD-95 (postsynaptic density protein 95) and GRIP1 (glutamate receptor interacting protein 1), effectively competing against dopamine transporter/DAT (Ki ~10 µM), GluR2 (Ki ~10 µM), and mRluR7a, c-terminus binding to PICK1 PDZ. Shown to accelerate internalized GluR2 surface recycling and suppress both long-term depression and potentiation in rat and murine hippocampal neurons.
    产品目录编号 529531
    品牌系列 Calbiochem®
    同义词 (E)-Ethyl-2-cyano-3-(3,4-dichlorophenyl)acryloylcarbamate
    参考
    参考 Thorsen, T.S., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 413.
    产品信息
    形式 Off-white solid
    Hill配方 C₁₃H₁₀Cl₂N₂O₃
    化学配方 C₁₃H₁₀Cl₂N₂O₃
    Molar Mass 313.1
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconsitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,529531,PICK1 PDZ Domain Inhibitor, FSC231 - Calbiochem

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