merck millipore,默克密理愽
  • merck millipore,默克密理博,14-931,CaMKK2, active

  • merck millipore,默克密理博,14-931,CaMKK2, active

    产品名称：CaMKK2, active
    产品型号：14-931


    merck millipore,默克密理博,14-931,CaMKK2, active

  • 产品介绍
  • merck millipore,默克密理博,14-931,CaMKK2, active

    描述
    产品目录编号 14-931
    商名
    • Upstate
    描述 CaMKK2, active
    概述 Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Isoform 1, isoform 2 and isoform 3 phosphorylate CAMK1 and CAMK4. Isoform 3 phosphorylates CAMK1D. Isoform 4, isoform 5 and isoform 6 lacking part of the calmodulin-binding domain are inactive. Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca2+ signals. Seems to be involved in hippocampal activation of CREB1. May play a role in neurite growth. Isoform 3 may promote neurite elongation, while isoform 1 may promoter neurite branching.
    产品信息
    演示 Protein in 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
    应用
    主要应用
    • Kinase Assay
    生物信息
    来源 N-terminal 6His-tagged, recombinant, human CaMKK2 full length, expressed by baculovirus in Sf21 insect cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_172226
    基因符号
    • CAMKK
    • CAMKK2
    • CAMKKB
    纯化方法 Purified using immobilized metal affinity chromatography.
    UniProt编号
    • Q96RR4
    产品使用声明
    质量保证 Routinely evaluated by phosphorylation of LSNLYHQGKFLQTFCGSPLYRRR
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 10 µg
    包装 Also available in 250μg size as catalog # 14-931M and in bulk as catalog # 14-931-K.

    merck millipore,默克密理博,14-931,CaMKK2, active

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