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品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB15328 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Olig2 Antibody 产品信息 格式 Affinity Purified 演示 Liquid in PBS containing 0.1% sodium azide. 应用 应用 This Anti-Olig2 Antibody is validated for use in WB for the detection of Olig2. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide from rat. 宿主 Rabbit 特异性 Oligodendrocyte marker Olig2. By Western blot the antibody recognizes a band at ~32 kDa in rat brain extract. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005806.2
Entrez基因汇总 This gene encodes a basic helix-loop-helix transcription factor which is expressed in oligodendroglial tumors of the brain. The protein is an essential regulator of ventral neuroectodermal progenitor cell fate. The gene is involved in a chromosomal translocation t(14;21)(q11.2;q22) associated with T-cell acute lymphoblastic leukemia. Its chromosomal location is within a region of chromosome 21 which has been suggested to play a role in learning deficits associated with Down syndrome. 基因符号 - Oligo2
- OLIG2
- bHLHB1
- RACK17
- OLIGO2
- BHLHB1
- PRKCBP2
纯化方法 Immunoaffinity purified UniProt编号 - Q13516
UniProt汇总 FUNCTION: SwissProt: Q13516 # Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).
SIZE: 323 amino acids; 32385 Da
SUBUNIT: Interacts with NKX2-2 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity).
TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
DOMAIN:SwissProt: Q13516 The bHLH is essential for interaction with NKX2-2 (By similarity).DISEASE:SwissProt: Q13516 # A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2-8degC in undiluted aliquots for up to 6 months after date of receipt. 包装信息 数量 100 µg
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