merck millipore,默克密理愽
  • merck millipore,默克密理博,ABT79,Anti-WASH complex subunit FAM21C Antibody

  • merck millipore,默克密理博,ABT79,Anti-WASH complex subunit FAM21C Antibody

    产品名称：Anti-WASH complex subunit FAM21C Antibody
    产品型号：ABT79
    Anti-WASH complex subunit FAM21C Antibody detects level of WASH complex subunit FAM21C & has been published & validated for use in WB & IC.

    merck millipore,默克密理博,ABT79,Anti-WASH complex subunit FAM21C Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABT79,Anti-WASH complex subunit FAM21C Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 ABT79
    描述 Anti-WASH complex subunit FAM21C Antibody
    Alternate Names
    • WASH complex subunit FAM21C
    • family with sequence similarity 21, member C
    • vaccinia virus penetration factor
    背景信息 FAM21C, also known as WASH complex subunit FAM21C, is a part of the a 500 kDa core complex that allows the Wiskott-Aldrich syndrome protein (WASH) function. FAM21C can be found in the membranes of early endosomes. FAM21C cooperates with CAPZ and hinders its actin-capping activity, links WASH to endosomes, and is required for WASH-dependent retromer-mediated sorting.
    产品信息
    格式 Purified
    控制
    • HEK293 cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-WASH complex subunit FAM21C Antibody detects level of WASH complex subunit FAM21C & has been published & validated for use in WB & IC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:500 dilutioin from a previous lot detected WASH complex subunit FAM21C in NIH/3T3, A431, and HeLa cells.
    生物信息
    免疫原品种 Recombinant protein corresponding to human WASH complex subunit FAM21C.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_056077
    基因符号
    • VPEF2
    • FAM21C
    • FAM21A
    纯化方法 Protein G Purified
    UniProt编号
    • Q9Y4E1
    UniProt汇总 FUNCTION: Component of the WASH complex, a complex present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. The WASH complex plays a key role in the fission of tubules that serve as transport intermediates during endosome sorting. In the complex, it probably mediates the recruitment of the complex to endosome membranes.

    SUBUNIT STRUCTURE: Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts (via N-terminus) with WASH1; the interaction is direct.

    SUBCELLULAR LOCATION: Early endosome membrane

    MISCELLANEOUS: In human, FAM21 has undergone evolutionary duplication, with 4 highly homologous family members existing, including FAM21A, FAM21B, FAM21C, and an N-terminally truncated FAM21D form.

    SEQUENCE SIMILARITIES: Belongs to the FAM21 family.

    SEQUENCE CAUTION: The sequence AAH06456.1 differs from that shown. Reason: Erroneous initiation.

    The sequence BAA25518.1 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in HEK293 cell lysate.

    Western Blot Analysis: 5 µg/mL of this antibody detected WASH complex subunit FAM21C in 10 µg of HEK293 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABT79,Anti-WASH complex subunit FAM21C Antibody

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