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merck millipore,默克密理博,CBL57,Anti-Adrenocorticotropic Hormone Antibody, NT, clone 57
产品名称：Anti-Adrenocorticotropic Hormone Antibody, NT, clone 57
产品型号：CBL57
This Anti-Adrenocorticotropic Hormone Antibody, N-terminus, clone 57 is validated for use in ELISA, IH(P) for the detection of Adrenocorticotropic Hormone.
merck millipore,默克密理博,CBL57,Anti-Adrenocorticotropic Hormone Antibody, NT, clone 57
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H ELISA M Purified Monoclonal Antibody 描述 产品目录编号 CBL57 Replaces CBL58 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Adrenocorticotropic Hormone Antibody, NT, clone 57 Alternate Names - ACTH
产品信息 格式 Purified 演示 The monoclonal is presented as 1mg in 1ml phosphate buffered saline containing 10mM sodium azide. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 This Anti-Adrenocorticotropic Hormone Antibody, N-terminus, clone 57 is validated for use in ELISA, IH(P) for the detection of Adrenocorticotropic Hormone. 主要应用 - ELISA
应用说明 This antibody reacts with solid phase ACTH either captured as part of a sandwich or adsorbed as a solid phase antigen and as such is suitable for serum assay development
The antibody is also reactive on formalin fixed paraffin wax embedded tissue and is therefore suitable for immunocyto-chemistry
Optimal working dilutions must be determined by the end user.生物信息 表位 N-terminus 克隆 57 宿主 Mouse 特异性 This antibody is specific for Synacthen (1-24 ACTH) and has no cross reaction with CLIP (ACTH 17-39). The antibody has an affinity constant greater than 10E11 L/mol.
KNOWN SPECIES CROSS REACTIVITY: Positive with rat N-terminal ACTH peptide同种型 IgG1 品种反应性 RatHuman 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001035256.1
- NM_000939.2
Entrez基因汇总 This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. 基因符号 - Pro-opiomelanocortin
- corticotropin-lipotrophin
- NPP
- MSH
- met-enkephalin
- CLIP
- gamma-MSH
- POMC
- pro-ACTH-endorphin
- adrenocorticotropin
- beta-LPH
- POC
- gamma-LPH
- LPH
- ACTH
- corticotropin
- beta-endorphin
- beta-MSH
- alpha-MSH
- pro-opiomelanocortin
- proopiomelanocortin
UniProt编号 - P01189
UniProt汇总 FUNCTION: SwissProt: P01189 # Beta-endorphin and Met-enkephalin are endogenous opiates.
SIZE: 267 amino acids; 29424 Da
TISSUE SPECIFICITY: ACTH and MSH are produced by the pituitary gland.
PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides. & O-glycosylated; reducing sugar is probably N- acetylgalactosamine.
DISEASE: SwissProt: P01189 # Defects in POMC may be associated with susceptibility to obesity [MIM:601665]. & Defects in POMC are the cause of pro-opiomelanocortinin deficiency [MIM:609734]. Affected individuals present early-onset obesity, adrenal insufficiency and red hair.
SIMILARITY: SwissProt: P01189 ## Belongs to the POMC family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 1 mg
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