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merck millipore,默克密理博,489478,LSD1 Inhibitor III, CBB1007 - Calbiochem
产品名称：LSD1 Inhibitor III, CBB1007 - Calbiochem
产品型号：489478
The LSD1 Inhibitor III, CBB1007 controls the biological activity of LSD1. This small molecule/inhibitor is primarily used for Cell Structure applications.
merck millipore,默克密理博,489478,LSD1 Inhibitor III, CBB1007 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₇H₃₄N₈O₄ • 3CF₃CO₂H 描述 概述 A cell-permeable amidino-guanidinium compound that acts as a potent, reversible and substrate competitive LSD1 selective inhibitor (IC50 = 5.27 µM for hLSD1) and efficiently blocks LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 µM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 µM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 µM). Shown to preferentially arrest the growth of pluripotent tumors with minimal effect on non-pluripotent cancer or normal somatic cells (IC50 > 100 µM). 产品目录编号 489478 品牌系列 Calbiochem®
同义词 Methyl-3-(4-(4-carbamimidoylbenzoyl)piperazine-1-carbonyl)-5-((4-carbamimidoylpiperazin-1-yl)methyl)benzoate, 3TFA, KDM1 Inhibitor III, Histone Lysine Demethylase Inhibitor V, BHC110 Inhibitor III, LSD Inhibitor III 参考 参考 Wang, J., et al. 2011. Cancer Res. 71, 7238. 产品信息 形式 White solid 配方 Supplied as a trifluoroacetate salt. Hill配方 C₂₇H₃₄N₈O₄ • 3CF₃CO₂H 化学配方 C₂₇H₃₄N₈O₄ • 3CF₃CO₂H 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥99% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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