merck millipore,默克密理愽
  • merck millipore,默克密理博,ABT11,Anti-Fibroblast activation protein alpha (FAP) Antibody

  • merck millipore,默克密理博,ABT11,Anti-Fibroblast activation protein alpha (FAP) Antibody

    产品名称：Anti-Fibroblast activation protein alpha (FAP) Antibody
    产品型号：ABT11
    Detect Fibroblast activation protein alpha (FAP) using this Anti-Fibroblast activation protein alpha (FAP) Antibody validated for use in WB, IH.

    merck millipore,默克密理博,ABT11,Anti-Fibroblast activation protein alpha (FAP) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABT11,Anti-Fibroblast activation protein alpha (FAP) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 ABT11
    描述 Anti-Fibroblast activation protein alpha (FAP) Antibody
    Alternate Names
    • 170 kDa melanoma membrane-bound gelatinase, FAP
    • fibroblast activation protein, alpha
    • fibroblast activation protein, alpha subunit
    • integral membrane serine protease
    • seprase
    背景信息 Fibroblast activation protein alpha (FAP), also known as Seprase, is a 97 kDa, type II cell surface glycoprotein belonging to the serine protease family. Although FAP is considered fibroblast specific, it is not found in normal healthy fibroblasts. FAP is most commonly found in stromal, tumor fibroblasts, and is likely involved in ECM pericellular proteolysis, endothelial cell migration and invasion into the ECM. The presence of FAP in human epithelial carcinoma is increased, particularly in breast, colorectal, lung, and ovarian carcinomas. FAP is also transiently observed in developing cells, or in tissues that are undergoing wound healing or suffering from chronic inflammatory conditions. Due to its specific distribution both to tumor fibroblasts and to inflammed tissue, FAP makes a promising target for research in tumor-stromal studies and in therapeutic studies.
    产品信息
    格式 Purified
    控制
    • HEK-FAP xenograft tumor lysate
    演示 Purified rabbit polyclonal in buffer containing PBS (pH 7.2) with 0.05% sodium azide.
    应用
    应用 Detect Fibroblast activation protein alpha (FAP) using this Anti-Fibroblast activation protein alpha (FAP) Antibody validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    应用说明 Immunohistochemistry: A 1:750 dilution of a previous lot of FAP antibody was used to immunohistochemically stain frozen tissue sections of HEK-FAP or HT-29 xenograft tumors from C.B17 mice (Cheng, 2002).

    Inhibition: Inhibition of dipeptidyl peptidase activity with a previous lot of FAP antibody on HT-29 xenograft tumors was demonstrated by an independent laboratory (Cheng, 2002).
    生物信息
    免疫原品种 Histidine-tagged recombinant protein corresponding to human FAP.
    表位 Extracellular domain
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 The antibody recognizes the extracellular domain of Fibroblast activation protein alpha
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_004451
    Entrez基因汇总 The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. [provided by RefSeq].
    基因符号
    • DPPIV
    • FAPA
    • FAP
    纯化方法 Ammonium Sulfate
    UniProt编号
    • Q12884
    UniProt汇总 FUNCTION: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers.

    CATALYTIC ACTIVITY: Degrades gelatin and heat-denatured type I and type IV collagen, but not native type I or type IV collagen. Does not cleave laminin, fibronectin, fibrin or casein.

    SUBUNIT STRUCTURE: Homodimer, or heterodimer with DPP4. The monomer is inactive.

    SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Cell projection › lamellipodium membrane; Single-pass type II membrane protein. Cell projection › invadopodium membrane; Single-pass type II membrane protein. Note: Found in cell surface lamellipodia, invadopodia and on shed vesicles. Colocalized with DPP4 in invadopodia and lamellipodia of migratory activated endothelial cells in collagenous matrix. Colocalized with DPP4 on endothelial cells of capillary-like microvessels but not large vessels within invasive breast ductal carcinoma.

    TISSUE SPECIFICTY: Fibroblast specific.

    INDUCTION: In fibroblasts at times and sites of tissue remodeling during development, tissue repair, and carcinogenesis.

    PTM: N-glycosylated. Ref.11 Ref.9

    The N-terminus may be blocked.

    SEQUENCE SIMILARITIES: Belongs to the peptidase S9B family.
    产品使用声明
    质量保证 Evaluated by Western Blot in HEK-FAP xenograft tumor lysate.

    Western Blot Analysis: 2.5 µg/mL of this antibody detected FAP in 10 µg of HEK-FAP xenograft tumor lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABT11,Anti-Fibroblast activation protein alpha (FAP) Antibody

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