merck millipore,默克密理愽
  • merck millipore,默克密理博,343022,Flt-3 Inhibitor III - CAS 852045-46-6 - Calbiochem

  • merck millipore,默克密理博,343022,Flt-3 Inhibitor III - CAS 852045-46-6 - Calbiochem

    产品名称：Flt-3 Inhibitor III - CAS 852045-46-6 - Calbiochem
    产品型号：343022
    The Flt-3 Inhibitor III, also referenced under CAS 852045-46-6, controls the biological activity of Flt-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli More>>

    merck millipore,默克密理博,343022,Flt-3 Inhibitor III - CAS 852045-46-6 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,343022,Flt-3 Inhibitor III - CAS 852045-46-6 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₁H₂₃N₃OS852045-46-6
    描述
    概述 A cell-permeable 5-phenyl-2-thiazolamine compound that acts as a potent, ATP binding site-targeting inhibitor of Flt3 (IC50 = 50 nM). It inhibits c-Kit, KDR, c-Abl, Cdk1, c-Src, and Tie-2 only at much higher concentrations (IC50 = 0.26, 0.91, 1.2, 2.1, 2.8, and 8.0 µM, respectively) and exhibits little activity against a panel of 12 other commonly studied kinases even at concentrations as high as 10 µM. Blocks FLT3-dependent cell proliferation in a dose-dependent manner (IC50 = 52, 240, and 760 nM in MV4:11-ITD, BaF3-ITD, and BaF3-D835/Y cells).
    产品目录编号 343022
    品牌系列 Calbiochem®
    同义词 5-Phenyl-N-(4-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-thiazolamine, (5-Phenyl-thiazol-2-yl)-(4-(2-pyrrolidin-1-yl-ethoxy)-phenyl)-amine
    参考
    参考 Furet, P., et al. 2006. J. Med. Chem. 49, 4451.
    产品信息
    CAS号 852045-46-6
    具有ATP竞争性 Y
    形式 Off-white solid
    Hill配方 C₂₁H₂₃N₃OS
    化学配方 C₂₁H₂₃N₃OS
    Molar Mass 365.5
    可逆 N
    结构配方图像
    生物信息
    主靶 Flt-3
    主靶IC50 50 nM against Flt3
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    安全信息
    R相 R: 20/21/22

    Harmful by inhalation, in contact with skin and if swallowed.
    S相 S: 26-36/37

    In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
    Wear suitable protective clothing and gloves.
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,343022,Flt-3 Inhibitor III - CAS 852045-46-6 - Calbiochem

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