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品种反应性 主要应用 宿主 格式 抗体类型 M WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT102 描述 Anti-Tks5, PX domain Antibody Alternate Names - Tyrosine kinase substrate with five SH3 domains
- SH3 and PX domain-containing protein 2A
- Adapter protein TKS5
- Five SH3 domain-containing protein
- SH3 multiple domains protein 1
背景信息 Tks5 (previously known as Fish), is a large scaffolding protein with one amino-terminal PX domain and five SH3 domains. It is cytoplasmic in normal fibroblasts. In Src-transformed cells, Tks5 localizes to podosomes. The coexpression of Tks5 and constitutively active Src in epithelial cancer cells resulted in the appearance of podosomes/invadopodia. Cells with reduced Tks5 expression are poorly invasive through matrigel. Tks5 is expressed and localized to podosomes/invadopodia in some invasive human cancer cell lines and tumor tissue, particularly breast cancers and melanomas. Thus, Tks5 appears to be required for podosome/invadopodia formation and for invasion of some cancer cells. 产品信息 格式 Affinity Purified 控制 - NIH/3T3 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect TKS using this rabbit polyclonal antibody, Anti-Tks5, PX domain Antibody validated for use in western blotting & IP. 主要应用 - Western Blotting
应用说明 Immunoprecipitation Analysis: 10 µg from a representative lot detected Tks5, PX domain in in 500 µg of NIH/3T3 cell lysate. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the PX domain of human Tks5. 表位 PX domain 宿主 Rabbit 特异性 This antibody specifically recognizes the PX domain of Tks5. 品种反应性 Mouse Species Reactivity Note Demonstrated to react with Mouse. Predicted to react with Human based upon immunogen design. Other homologies: Rat (69% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_055446
基因符号 - TKS5
- SH3PXD2A
- FISH
- SH3MD1
纯化方法 Affinity purified UniProt编号 - Q5TCZ1
产品使用声明 质量保证 Evaluated by Western Blotting in NIH/3T3 cell lysate.
Western Blotting Analysis: A 1:250 dilution of this antibody detected Tks5, PX domain in 10 µg of NIH/3T3 cell lysate (Note: Tks5 was first immunoprecipitated from NIH/3T3 cell lysate using Cat. No. 09-268, Anti-TKS5 (SH3 #4), prior to Western Blotting Analysis.).使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µL
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