merck millipore,默克密理愽
  • merck millipore,默克密理博,MABE306,Anti-Dnmt1 Antibody, clone DNM-2C1

  • merck millipore,默克密理博,MABE306,Anti-Dnmt1 Antibody, clone DNM-2C1

    产品名称：Anti-Dnmt1 Antibody, clone DNM-2C1
    产品型号：MABE306
    Anti-Dnmt1 Antibody, clone DNM-2C1 is a Rat Monoclonal Antibody for detection of Dnmt1 also known as DNA (cytosine-5)-methyltransferase 1 & has been validated in IP, ChIP & WB.

    merck millipore,默克密理博,MABE306,Anti-Dnmt1 Antibody, clone DNM-2C1

  • 产品介绍
  • merck millipore,默克密理博,MABE306,Anti-Dnmt1 Antibody, clone DNM-2C1

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HChIP, WBRPurifiedMonoclonal Antibody
    描述
    产品目录编号 MABE306
    描述 Anti-Dnmt1 Antibody, clone DNM-2C1
    Alternate Names
    • DNA Mtase Hsal, M. H.sal, MCMT
    • DNA (cytosine-5)-methyltransferase 1
    • Dnmt1
    • CXXC-type zinc finger protein 9
    • DNA methyltransferase HsaI
    背景信息 DNA (cytosine-5)-methyltransferase 1 (Dnmt1) is one of three mammalian enzymes that catalyze the addition of a methyl group to the 5’ carbon of cytosine residues in CpG dinucleotides. These methylation marks are heritable modifications that are transferred to new DNA molecules following replication, by the activity of Dnmt1, and possibly Dnmt3a and Dnmt3b. Dnmt1 recognizes hemimethylated CpG regions with the aid of the UHRF1 protein, and it mediates the methylation of cytosines at those sites. DNA methylation has been linked to chromosome stability and gene expression in somatic cells; and to parental imprinting and X-chromosome inactivation in germ cells. Several studies have indicated that DNA methylation patterns are altered in various cancers.
    产品信息
    格式 Purified
    控制
    • HeLa nuclear extract
    演示 Purified rat monoclonal IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-Dnmt1 Antibody, clone DNM-2C1 is a Rat Monoclonal Antibody for detection of Dnmt1 also known as DNA (cytosine-5)-methyltransferase 1 & has been validated in IP, ChIP & WB.
    主要应用
    • Chromatin Immunoprecipitation (ChIP)
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to detect Dnmt1 in IP (Felle, M., et al. (2011). Nucleic Acids Res. 39(19):8355-8365.).

    Chromatin Immunoprecipitation Analysis: A representative lot was used by an independent laboratory to immunoprecipitate Dnmt1 in ChIP (Felle, M., et al. (2011). Nucleic Acids Res. 39(19):8355-8365.).
    生物信息
    免疫原品种 His-tagged recombinant protein corresponding to human Dnmt1.
    克隆 DNM-2C1
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rat
    同种型 IgG2b
    品种反应性 Human
    Species Reactivity Note Demonstrated to react with Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001124295
    基因符号
    • DNMT
    • DNMT1
    • AIM
    • CXXC9
    纯化方法 Protein G purified
    UniProt编号
    • P26358
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa nuclear extract.

    Western Blot Analysis: 0.02 µg/mL of this antibody detected Dnmt1 in 10 µg of HeLa nuclear extract.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,MABE306,Anti-Dnmt1 Antibody, clone DNM-2C1

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