merck millipore,默克密理愽
  • merck millipore,默克密理博,565773,γ-Secretase Inhibitor XII - Calbiochem

  • merck millipore,默克密理博,565773,γ-Secretase Inhibitor XII - Calbiochem

    产品名称：γ-Secretase Inhibitor XII - Calbiochem
    产品型号：565773
    The γ-Secretase Inhibitor XII controls the biological activity of γ-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.

    merck millipore,默克密理博,565773,γ-Secretase Inhibitor XII - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,565773,γ-Secretase Inhibitor XII - Calbiochem

    重要规格表

    经验配方
    C₂₀H₃₀N₂O₄
    描述
    概述 A cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
    产品目录编号 565773
    品牌系列 Calbiochem®
    同义词 Z-IL-CHO
    参考
    参考 Weijzen, S., et al. 2002. Nat. Med. 8, 979.
    McLendon, C., et al. 2000. FASEB J. 14, 2383.
    产品信息
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₀H₃₀N₂O₄
    化学配方 C₂₀H₃₀N₂O₄
    Molar Mass 362.5
    肽序列 Z-Ile-Leu-CHO
    可逆 Y
    结构配方图像
    生物信息
    主靶 Aβ40 in vitro
    主靶IC50 7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    肽序列 Z-Ile-Leu-CHO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,565773,γ-Secretase Inhibitor XII - Calbiochem

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