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品种反应性 主要应用 宿主 格式 抗体类型 M IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS436 Replaces MABN1037 描述 Anti-ROCK2 Antibody Alternate Names - ROCK2
- Rho-associated coiled-coil containing protein kinase 2
- Rho-associated protein kinase 2
- Rho-associated, coiled-coil-containing protein kinase II
- p164 ROCK-2
背景信息 Rho-associated protein kinase 2 (ROCK2), also known as Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase II, and p164 ROCK-2, is a member of the AGC serine/threonine protein kinase family. ROCK2 is a key regulator of actin cytoskeleton and cell polarity. It is involved in regulation of actin cytoskeleton organization, smooth muscle contraction, malignant cell transformation, tumor invasion and metastasis, stress fiber and focal adhesion formation, neurite retraction, motility and cell adhesion. Many of the key roles of ROCK2 are attributed to its ability to phosphorylate ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A, VIM, SORL1 and IRF4. ROCK2 regulates positively the activation of p42/MAPK1-p44/MAPK3 and the regulation of p90RSK/RPS6KA1 during myogenic differentiation. Alternatively, ROCK2 is a negative regulator of VEGF-induced angiogenic endothelial cell activation. Recent studies have shown that ROCK2 inhibits keratinocyte terminal differentiation and may play an important role in the timely initiation of centrosome duplication. It also may regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Additional evidence suggests that ROCK2 plays a critical role in the regulation of spine and synaptic properties in the hippocampus. 产品信息 格式 Affinity Purified 控制 - Mouse brain tissue lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-ROCK2 Antibody is a highly specific rabbit polyclonal antibody, that targets Rho-associated protein kinase 2 & has been tested in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 5 µg/mL from a representative lot detected ROCK2 in mouse brain tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human ROCK2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Mouse 抗体类型 Polyclonal Antibody 基因符号 - ROCK2
纯化方法 Antigen Affinity purified UniProt编号 - O75116
产品使用声明 质量保证 Evaluated by Western Blotting in mouse brain tissue lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected ROCK2 in 15 µg of mouse brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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