- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 ABS53 描述 Anti-FHOD1 Antibody Alternate Names - Formin homolog overexpressed in spleen 1
- formin homology 2 domain containing 1
- FHOS
- FH1/FH2 domain-containing protein
- FHOS1
- Formin homology 2 domain-containing protein 1
背景信息 Formin-homology-2-domain containing protein 1 (FHOD1) is a member of the forming homology (FH) family, a group of proteins that act to regulate several cellular processes such as; embryonic patterning, cell survival, cytoskeletal organization, gene transcription and migration. FH proteins are able to regulate these processes through their interaction with actin binding proteins and by serving to bridge Rho-family GTPases with Src tyrosine kinase and the pathway for Wnt Signaling. As a member of the FH family, FHOD1 contains several characteristic domains including; a GTPase Binding Domain (GBD, a coiled coil, FH1 and FH2 domains, and a Diaphanous-like autoregulatory domain (DAD). FHOD1 is a necessary component in F-actin structure assembly and its activity is dependant on the RHO-Rock. Expression of FHOD1 is ubiquitous, but is highest in the spleen. 产品信息 格式 Purified 控制 - Huvec cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-FHOD1 Antibody is an antibody against FHOD1 for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 2 µg/mL of this antibody detected FHOD1 on 10 µg of HeLa cell lysate. 生物信息 免疫原品种 Linear peptide corresponding to human FHOD1 at the N-terminus. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes FHOD1 at the N-terminus. 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_037373
Entrez基因汇总 This gene encodes a protein which is a member of the formin/diaphanous family of proteins. The gene is ubiquitously expressed but is found in abundance in the spleen. The encoded protein has sequence homology to diaphanous and formin proteins within the Formin Homology (FH)1 and FH2 domains. It also contains a coiled-coil domain, a collagen-like domain, two nuclear localization signals, and several potential PKC and PKA phosphorylation sites. It is a predominantly cytoplasmic protein and is expressed in a variety of human cell lines. [provided by RefSeq]. 基因符号 - FHOD1
纯化方法 Protein G purfied UniProt编号 - Q9Y613
UniProt汇总 FUNCTION: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation.
SUBUNIT STRUCTURE: Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm › cytoskeleton. Note: Predominantly cytoplasmic.
TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen.
DOMAIN: Regulated by intramolecular binding to a C-terminal auto-inhibitory domain. Effector binding abolishes this interaction and activates the protein.
SEQUENCE SIMILARITIES: Belongs to the formin homology family.
Contains 1 FH1 (formin homology 1) domain.
Contains 1 FH2 (formin homology 2) domain.
Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.产品使用声明 质量保证 Evaluated by Western Blot in Huvec cell lysate.
Western Blot Analysis: 2 µg/mL of this antibody detected FHOD1 on 10 µg of Huvec cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,S-002-10F,Cell Culture Freezing Media With Dmso
下一件merck millipore产品：merck millipore,默克密理博,681671,Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem
相关产品
merck millipore,默克密理博,MABT82,Anti-JAM-C Antibody, clone H36
merck millipore,默克密理博,178251,α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem
merck millipore,默克密理博,14-664M,Mnk2 Protein, active, 250 µg
merck millipore,默克密理博,S-002-10F,Cell Culture Freezing Media With Dmso
merck millipore,默克密理博,681671,Wnt Antagonist II, IWP-2 - CAS 686770-61-6 - Calbiochem
merck millipore,默克密理博,AB9680,Anti-GABA A Receptor β 1 Antibody
merck millipore,默克密理博,480457,NF-κB Activation Inhibitor VII, CID-2858522 - Calbiochem
%5BABE454_IHC(P)-ALL%5D.jpg "merck millipore,默克密理博,ABE454,Anti-IDH Antibody")
merck millipore,默克密理博,ABE454,Anti-IDH Antibody
merck millipore,默克密理博,04-968,Anti-Folr4 (Folate receptor 4) Antibody, clone 5E12.2